INT13085

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 50
Total Number 55
Disease Relevance 44.20
Pain Relevance 8.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
plasma 4
smooth muscle cells 3
platelet 2
Blood 2
Chest 1
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 154 100.00 Very High Very High Very High
bradykinin 79 100.00 Very High Very High Very High
Opioid 4 99.88 Very High Very High Very High
methotrexate 48 99.84 Very High Very High Very High
Calcium channel 13 99.12 Very High Very High Very High
Enkephalin 14 98.78 Very High Very High Very High
dexamethasone 3 98.72 Very High Very High Very High
corticosteroid 32 98.16 Very High Very High Very High
Migraine 124 97.64 Very High Very High Very High
anticonvulsant 4 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 163 100.00 Very High Very High Very High
Granuloma 102 100.00 Very High Very High Very High
Stress 60 100.00 Very High Very High Very High
Pressure And Volume Under Development 111 99.96 Very High Very High Very High
Cough 38 99.96 Very High Very High Very High
Lung Injury 17 99.96 Very High Very High Very High
Factor Xi Deficiency 4 99.96 Very High Very High Very High
Pleural Effusion 3 99.88 Very High Very High Very High
Gauchers Disease 120 99.68 Very High Very High Very High
Atherosclerotic Plaque 8 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of granulomas with an elevated angiotensin-converting enzyme level is not pathognomonic for sarcoidosis.
Positive_regulation (elevated) of angiotensin-converting enzyme associated with sarcoidosis and granuloma
1) Confidence 0.70 Published 2003 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 12701398 Disease Relevance 1.26 Pain Relevance 0.26
The serum angiotensin converting enzyme levels, which are postulated to derive from undiscovered granulomas, were found to be elevated.
Positive_regulation (elevated) of angiotensin converting enzyme associated with granuloma
2) Confidence 0.70 Published 1989 Journal South. Med. J. Section Abstract Doc Link 2536197 Disease Relevance 0.83 Pain Relevance 0.33
On the basis of an elevated angiotensin-converting enzyme level of 160 U/L and anemia, a bone marrow biopsy was performed.
Positive_regulation (elevated) of angiotensin-converting enzyme in bone marrow associated with anaemia
3) Confidence 0.69 Published 2004 Journal South. Med. J. Section Abstract Doc Link 15255428 Disease Relevance 2.14 Pain Relevance 0.18
The serum angiotensin converting enzyme level was elevated.
Positive_regulation (elevated) of angiotensin converting enzyme
4) Confidence 0.69 Published 2000 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 11033520 Disease Relevance 0.87 Pain Relevance 0.48
Individuals who were homozygous for the deletion (D) allele showed increased ACE activity levels.
Positive_regulation (increased) of ACE
5) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15644278 Disease Relevance 0.81 Pain Relevance 0.59
The biopsy specimens of the leg with crusts showed the presence of epithelioid granuloma, and because of a negative tuberculin test, increased serum angiotensin converting enzyme (ACE) and lysozyme levels, and pulmonary Ga uptake, the patient was given a diagnosis of sarcoidosis.
Positive_regulation (increased) of angiotensin converting enzyme in leg associated with sarcoidosis and granuloma
6) Confidence 0.69 Published 2007 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 17929471 Disease Relevance 1.32 Pain Relevance 0.08
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (accumulation) of ACE in plaque associated with atherosclerotic plaque and pressure and volume under development
7) Confidence 0.68 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.70 Pain Relevance 0.10
Together with these findings an increased activity of the angiotensin-converting-enzyme (ACE) indicated sarcoidosis, other causes having been excluded.
Positive_regulation (increased) of ACE
8) Confidence 0.67 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9987484 Disease Relevance 0.07 Pain Relevance 0
The serum level of angiotensin-converting enzyme was elevated.
Positive_regulation (elevated) of angiotensin-converting enzyme
9) Confidence 0.67 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 16457341 Disease Relevance 1.02 Pain Relevance 0.03
A critical role of an Arg residue in ACE and, to a lesser extent, in "enkephalinase" (but not in thermolysin) is suggested to be responsible for the preferential dipeptidylcarboxypeptidase activity of these two enzymes.
Positive_regulation (responsible) of dipeptidylcarboxypeptidase
10) Confidence 0.67 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2992465 Disease Relevance 0 Pain Relevance 0.29
Increased ACE maintains efficacy during the interdose periods of extended-interval regimens (Zaidi et al 2007).
Positive_regulation (Increased) of ACE
11) Confidence 0.67 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682394 Disease Relevance 0.05 Pain Relevance 0
Serum angiotensin converting enzyme (SACE) level was elevated.
Positive_regulation (elevated) of Serum angiotensin converting enzyme
12) Confidence 0.61 Published 1995 Journal Sarcoidosis Section Abstract Doc Link 7617983 Disease Relevance 0.32 Pain Relevance 0.08
The action of ACE-I on platelets could be related to Ang II blockade.
Positive_regulation (related) of ACE-I in platelets
13) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.50 Pain Relevance 0.13
The antiatherogenic ACE-I properties may be related both to the inhibition of tissue and circulating Ang II formation and to bradykinin potentiation, resulting in decreased proliferation and migration of smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and increased endothelial NO formation, leading to improved endothelial function.
Neg (NO) Positive_regulation (increased) of ACE-I in smooth muscle cells associated with stress, inflammation and bradykinin
14) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.95 Pain Relevance 0.15
To examine the mechanisms of an angiotensin-converting enzyme (ACE) inhibitor-induced cough in perimenopausal and postmenopausal women, cough responses to aerosols of capsaicin and citric acid were examined in four groups of female guinea pigs treated orally with danazol (D) (an agent decreasing plasma estrogen levels), cilazapril (C) (an inhibitor of ACE), both danazol and cilazapril (C+D), or without either drug (control group) for 4 to 5 wk.
Spec (examine) Positive_regulation (inhibitor-induced) of ACE in plasma associated with qutenza and cough
15) Confidence 0.49 Published 1996 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 8564137 Disease Relevance 0.34 Pain Relevance 0.23
The study included 16 consecutive patients with a chronic progressive severe refractory heart failure (sHF) of NYHA class III (n = 6) or IV (n = 10) who did not respond to diuretics and angiotension converting enzyme (ACE) inhibitors.
Neg (not) Positive_regulation (respond) of ACE in heart associated with myocardial infarction
16) Confidence 0.49 Published 1996 Journal Perit Dial Int Section Abstract Doc Link 8728198 Disease Relevance 0.93 Pain Relevance 0.05
Markedly increased ACE immunoreactivity has been demonstrated in human myocytes adjacent to infarct scars [21].
Positive_regulation (increased) of ACE in myocytes associated with cicatrix
17) Confidence 0.48 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 0.43 Pain Relevance 0.10
Together with these findings an increased activity of the angiotensin-converting-enzyme (ACE) indicated sarcoidosis, other causes having been excluded.
Positive_regulation (activity) of angiotensin-converting-enzyme
18) Confidence 0.47 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9987484 Disease Relevance 0.07 Pain Relevance 0
Together with these findings an increased activity of the angiotensin-converting-enzyme (ACE) indicated sarcoidosis, other causes having been excluded.
Positive_regulation (increased) of angiotensin-converting-enzyme
19) Confidence 0.47 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9987484 Disease Relevance 0.07 Pain Relevance 0
Melkersson-Rosenthal syndrome: elevations in serum angiotensin converting enzyme and results of treatment with methotrexate.
Positive_regulation (elevations) of angiotensin converting enzyme associated with factor xi deficiency and methotrexate
20) Confidence 0.47 Published 1989 Journal South. Med. J. Section Title Doc Link 2536197 Disease Relevance 0.79 Pain Relevance 0.35

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