INT130850

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.46
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bgn) proteinaceous extracellular matrix (Bgn)
Anatomy Link Frequency
tendon 4
Bgn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tendinopathy 10 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In painful tendinopathy both aggrecan and biglycan mRNA expression increased (more than 10-fold and 5-fold, respectively) compared with normal tendon samples, but levels of versican and decorin mRNA were not significantly changed.
Transcription (expression) of biglycan in tendon
1) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVES: To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons.
Spec (determine) Transcription (expression) of biglycan in tendons associated with pain and tendinopathy
2) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Abstract Doc Link 16219640 Disease Relevance 0.17 Pain Relevance 0.10
CONCLUSIONS: Increased aggrecan and biglycan mRNA expression in painful tendinopathy resembles the pattern in fibrocartilaginous regions of tendon, and may reflect an altered mechanical environment at the site of the lesion.
Transcription (expression) of biglycan in tendon
3) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0.06 Pain Relevance 0
Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy.
Transcription (expression) of biglycan associated with tendinopathy
4) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Title Doc Link 16219640 Disease Relevance 0.10 Pain Relevance 0.09
In ruptured tendons the levels of aggrecan, biglycan and versican mRNA were not changed compared with normal tendon samples, but decorin mRNA decreased markedly.
Transcription (levels) of biglycan in tendon
5) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0.06 Pain Relevance 0

General Comments

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