INT130865

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 12.82
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoclast 7
macrophage 2
osteoblasts 2
T cells 2
MCF-7 1
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 109 99.82 Very High Very High Very High
Osteoarthritis 546 99.76 Very High Very High Very High
imagery 27 99.14 Very High Very High Very High
rheumatoid arthritis 114 93.32 High High
Inflammation 90 90.84 High High
Arthritis 121 86.68 High High
Analgesic 1 86.28 High High
cINOD 11 85.92 High High
Pain 33 81.64 Quite High
Bioavailability 8 80.36 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 543 99.76 Very High Very High Very High
Cancer 69 99.72 Very High Very High Very High
Necrosis 15 99.48 Very High Very High Very High
Hypercalcemia 134 99.44 Very High Very High Very High
Adult T-cell Leukemia-lymphoma 17 99.42 Very High Very High Very High
Osteoporosis 244 99.12 Very High Very High Very High
Celiac Disease 128 98.20 Very High Very High Very High
Breast Cancer 48 96.00 Very High Very High Very High
Osteopetrosis 144 94.44 High High
Rheumatoid Arthritis 114 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease again appeared to be the result of the CS effect, as GS upregulated the expression level of RANKL at the highest concentration.
Positive_regulation (upregulated) of RANKL
1) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
Data showed (Figure 2c) that, under basal conditions, the expression ratio of OPG/RANKL was significantly increased when cells were incubated with CS alone and in combination with GS.
Positive_regulation (increased) of RANKL
2) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.09 Pain Relevance 0.09
Such CS- and/or GS-independent effects could explain our findings in which, although an increase in the OPG/RANKL ratio is found upon treatment with CS, it appears insufficient to significantly reduce bone resorption.
Positive_regulation (increase) of RANKL associated with hypercalcemia
3) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.28 Pain Relevance 0
Only EP2/EP4 agonists reproduced the effects of PGE(2) on OPG and RANKL induction.
Positive_regulation (induction) of RANKL
4) Confidence 0.60 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.12 Pain Relevance 0
The levels of both soluble and membrane type RANKL were elevated in IFN-gamma(+) T cells.
Positive_regulation (elevated) of RANKL in T cells
5) Confidence 0.54 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16220542 Disease Relevance 0.34 Pain Relevance 0.25
The fibroblastic cells from the SF of TMD patients were positive for fibroblast markers and RANKL mRNA was up-regulated.
Positive_regulation (up-regulated) of RANKL mRNA in fibroblast
6) Confidence 0.50 Published 2007 Journal Osteoarthr. Cartil. Section Body Doc Link 16979913 Disease Relevance 0 Pain Relevance 0
We previously demonstrated that OA subchondral bone osteoblasts can be discriminated into two subgroups and that both OPG and RANKL expression levels, and consequently the expression ratio of OPG/RANKL, differ according to the metabolic state of human OA subchondral bone osteoblasts: OPG/RANKL is decreased in L- and increased in H-OA osteoblasts[11].
Positive_regulation (increased) of RANKL in osteoblasts associated with osteoarthritis
7) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.97 Pain Relevance 0.40
(Interestingly, we further showed that L-OA osteoblasts promote osteoclast differentiation and formation and an increase in RANKL levels leading to a decreased OPG/RANKL expression ratio in favor of bone destruction [11].
Positive_regulation (increase) of RANKL in osteoclast associated with osteoarthritis
8) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.94 Pain Relevance 0.25
Data showed that vitamin D3 had no effect on the OPG gene expression and protein levels but markedly increased RANKL and, as a result, significantly inhibited the expression ratio of OPG/RANKL.
Positive_regulation (increased) of RANKL
9) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.11 Pain Relevance 0.07
Receptor activator of nuclear factor-kappaB ligand (RANKL), a member of the tumor necrosis factor (TNF) ligand family, plays an important role in osteoclastogenesis from osteoclast precursors to mature osteoclasts.
Positive_regulation (activator) of RANKL in osteoclasts associated with necrosis and cancer
10) Confidence 0.46 Published 2006 Journal Pharmacology Section Abstract Doc Link 16636611 Disease Relevance 0.74 Pain Relevance 0.13
Exposure of cells to strontium ranelate in vitro increases the ratio of osteoprotegerin to receptor activator of nuclear factor kappa B ligand (OPG/RANKL) in the medium, while treatment of cells reduces resorption in calvaria [18, 19].
Positive_regulation (activator) of RANKL
11) Confidence 0.45 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0.19 Pain Relevance 0
The concentration of soluble receptor activator of NF-kappaB ligand (RANKL) and IFN-gamma, and the amount of membrane type RANKL expressed on T cells, were measured by ELISA.
Positive_regulation (activator) of RANKL in T cells
12) Confidence 0.42 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16220542 Disease Relevance 0.26 Pain Relevance 0.17
Compared with controls, co-culture of MCF-7 induced differentiation of multinucleated cells by membrane-bound and soluble receptor activator of NF-kB ligand (RANKL) as quantified by ELISA, Western blot analysis, transmission electron microscopy (TEM), and immunocytochemistry.
Positive_regulation (activator) of RANKL in MCF-7
13) Confidence 0.42 Published 2008 Journal Acta Histochem. Section Abstract Doc Link 18406448 Disease Relevance 0.74 Pain Relevance 0.08
However, the expression ratio of OPG/RANKL obtained when cells were treated with GS was not increased.
Neg (not) Positive_regulation (increased) of RANKL
14) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.04
Importantly, under basal conditions, CS and both compounds combined significantly upregulated the expression ratio of OPG/RANKL.
Positive_regulation (upregulated) of RANKL
15) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.32 Pain Relevance 0.16
-induced increase in RANKL and OPG mRNA expression to control levels.
Positive_regulation (increase) of RANKL
16) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
In the bone tissue, osteoclast differentiation seems tightly associated with signaling related to RANKL (receptor activator of nuclear factor-?
Positive_regulation (activator) of RANKL in bone tissue
17) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.59 Pain Relevance 0.07
Other important signals for osteoclast differentiation include the ligand of receptor activator of nuclear factor-kappa B (RANKL) and M-CSF.
Positive_regulation (activator) of nuclear factor-kappa B in osteoclast
18) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.55 Pain Relevance 0
Other important signals for osteoclast differentiation include the ligand of receptor activator of nuclear factor-kappa B (RANKL) and M-CSF.
Positive_regulation (activator) of RANKL in osteoclast
19) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.55 Pain Relevance 0
Receptor activator of nuclear factor kappa-B ligand (RANKL), macrophage colony-stimulating factor (M-CSF), and TNF?
Positive_regulation (activator) of RANKL in macrophage
20) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0

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