INT130866

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 7.11
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
chondrocytes 4
multinucleated giant cells 4
stromal cells 3
osteoblast 3
Th1 cells 2
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 99 100.00 Very High Very High Very High
methotrexate 11 99.14 Very High Very High Very High
Osteoarthritis 408 98.64 Very High Very High Very High
Inflammation 78 98.48 Very High Very High Very High
rheumatoid arthritis 106 97.36 Very High Very High Very High
Arthritis 15 96.80 Very High Very High Very High
Snapping jaw 56 85.20 High High
Bioavailability 8 81.32 Quite High
cINOD 10 77.00 Quite High
agonist 3 74.44 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 282 99.92 Very High Very High Very High
Endometriosis (extended) 10 99.72 Very High Very High Very High
Osteoarthritis 407 98.64 Very High Very High Very High
INFLAMMATION 88 98.48 Very High Very High Very High
Hypercalcemia 108 98.00 Very High Very High Very High
Rheumatoid Arthritis 106 97.36 Very High Very High Very High
Arthritis 14 96.80 Very High Very High Very High
Disease 73 96.72 Very High Very High Very High
Postmenopausal Osteoporosis 13 94.24 High High
Cancer 239 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D3 drastically upregulated RANKL expression.
Positive_regulation (upregulated) of Gene_expression (expression) of RANKL
1) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
This decrease again appeared to be the result of the CS effect, as GS upregulated the expression level of RANKL at the highest concentration.
Positive_regulation (upregulated) of Gene_expression (expression) of RANKL
2) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
Consistent with the results obtained for gene expression, RANKL protein expression was significantly higher in the presence of IL-1?
Positive_regulation (higher) of Gene_expression (expression) of RANKL
3) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
As a result, OPG and RANKL expression increased with IL-1?
Positive_regulation (increased) of Gene_expression (expression) of RANKL
4) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.06 Pain Relevance 0.03
induces the expression of OPG and RANKL in human chondrocytes via an autocrine mechanism that increases PGE2 production.
Positive_regulation (induces) of Gene_expression (expression) of RANKL in chondrocytes
5) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.07 Pain Relevance 0
METHODS: To induce RANKL expression, IL-1beta was added to serum-free medium HPDL cells and incubated.
Positive_regulation (induce) of Gene_expression (expression) of RANKL in HPDL
6) Confidence 0.49 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
Yet CS and both compounds together increase the expression ratio of OPG/RANKL, suggesting a positive effect on OA subchondral bone structural changes.
Positive_regulation (increase) of Gene_expression (expression) of RANKL associated with osteoarthritis
7) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.23 Pain Relevance 0.11
In human OA chondrocytes in culture, PGE(2) elicited a dose- and time-dependent increase in the synthesis of RANKL, the extent of which was greater than that of OPG.
Positive_regulation (increase) of Gene_expression (synthesis) of RANKL in chondrocytes
8) Confidence 0.46 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.14 Pain Relevance 0
In this study, RANKL and OPG expression increased significantly in cells cultured with IL-1?
Positive_regulation (increased) of Gene_expression (expression) of RANKL
9) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.24 Pain Relevance 0.12
Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA.
Positive_regulation (induced) of Gene_expression (expression) of RANKL in Th1 cells associated with rheumatoid arthritis, hypercalcemia and disease
10) Confidence 0.45 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16220542 Disease Relevance 0.61 Pain Relevance 0.25
IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL.
Positive_regulation (induce) of Gene_expression (expression) of RANKL in T cells associated with methotrexate
11) Confidence 0.45 Published 2005 Journal Eur. J. Immunol. Section Title Doc Link 16220542 Disease Relevance 0.28 Pain Relevance 0.23
Data showed (Figure 2c) that, under basal conditions, the expression ratio of OPG/RANKL was significantly increased when cells were incubated with CS alone and in combination with GS.
Positive_regulation (increased) of Gene_expression (expression) of RANKL
12) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.09 Pain Relevance 0.09
Importantly, under basal conditions, CS and both compounds combined significantly upregulated the expression ratio of OPG/RANKL.
Positive_regulation (upregulated) of Gene_expression (expression) of RANKL
13) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.32 Pain Relevance 0.16
However, the expression ratio of OPG/RANKL obtained when cells were treated with GS was not increased.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of RANKL
14) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.04
Deschner et al. [33] reported that fibrochondrocytes constitutively expressed low levels of RANKL, but high levels of OPG; the authors reported that IL-1?
Positive_regulation (levels) of Gene_expression (levels) of RANKL
15) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.21 Pain Relevance 0.11
upregulated the expression and synthesis of RANKL; whereas OPG expression was unaffected after 4 and 24 hours.
Positive_regulation (upregulated) of Gene_expression (expression) of RANKL
16) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.21 Pain Relevance 0.10
showed the same effect for the expression of RANKL, M-CSF, and OPG for any culture period, while the control value changed in the long-term culture.
Positive_regulation (effect) of Gene_expression (expression) of RANKL
17) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
, which upregulate expression of RANKL on osteoblast/stromal cells (Table 1) [26,34].
Positive_regulation (upregulate) of Gene_expression (expression) of RANKL in osteoblast associated with osteoporosis
18) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.94 Pain Relevance 0.05
RANKL expression is increased after menopause, whereas estrogens stimulate OPG production [147].
Positive_regulation (increased) of Gene_expression (expression) of RANKL associated with endometriosis (extended)
19) Confidence 0.26 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.50 Pain Relevance 0
The complete estrogen deprivation may lead to an increased production of the cytokine RANKL by stromal cells and increased activity of RANK, thus leading to increased numbers of osteoclastic precursors and osteoclastogenesis.
Positive_regulation (increased) of Gene_expression (production) of RANKL in stromal cells associated with osteoporosis and cytokine
20) Confidence 0.19 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.54 Pain Relevance 0.09

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