INT130867

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 106
Total Number 111
Disease Relevance 45.15
Pain Relevance 10.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoblasts 14
chondrocytes 12
stromal cells 7
T cells 6
cartilage 4
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 400 100.00 Very High Very High Very High
rheumatoid arthritis 180 99.98 Very High Very High Very High
cINOD 51 99.58 Very High Very High Very High
Inflammation 378 99.22 Very High Very High Very High
imagery 26 99.14 Very High Very High Very High
Osteoarthritis 1701 99.04 Very High Very High Very High
methotrexate 15 98.04 Very High Very High Very High
Arthritis 39 96.16 Very High Very High Very High
Snapping jaw 252 91.52 High High
Pain 159 90.40 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 180 99.98 Very High Very High Very High
Osteoporosis 1235 99.92 Very High Very High Very High
Cancer 914 99.84 Very High Very High Very High
Osteolysis 112 99.66 Very High Very High Very High
Metastasis 843 99.60 Very High Very High Very High
Targeted Disruption 39 99.60 Very High Very High Very High
Adult T-cell Leukemia-lymphoma 17 99.58 Very High Very High Very High
INFLAMMATION 421 99.46 Very High Very High Very High
Endometriosis (extended) 29 99.20 Very High Very High Very High
Osteoarthritis 1699 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under basal conditions, RANKL expression was significantly reduced by CS and by both drugs incubated together.
Gene_expression (expression) of RANKL
1) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.39 Pain Relevance 0.17
We previously demonstrated that OA subchondral bone osteoblasts can be discriminated into two subgroups and that both OPG and RANKL expression levels, and consequently the expression ratio of OPG/RANKL, differ according to the metabolic state of human OA subchondral bone osteoblasts: OPG/RANKL is decreased in L- and increased in H-OA osteoblasts[11].
Gene_expression (expression) of RANKL in osteoblasts associated with osteoarthritis
2) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.80 Pain Relevance 0.35
Osteoprotegerin and RANKL expression and synthesis
Gene_expression (expression) of RANKL
3) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.36 Pain Relevance 0.12
We previously demonstrated that OA subchondral bone osteoblasts can be discriminated into two subgroups and that both OPG and RANKL expression levels, and consequently the expression ratio of OPG/RANKL, differ according to the metabolic state of human OA subchondral bone osteoblasts: OPG/RANKL is decreased in L- and increased in H-OA osteoblasts[11].
Gene_expression (expression) of RANKL in osteoblasts associated with osteoarthritis
4) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.77 Pain Relevance 0.34
This decrease again appeared to be the result of the CS effect, as GS upregulated the expression level of RANKL at the highest concentration.
Gene_expression (expression) of RANKL
5) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
Vitamin D3 drastically upregulated RANKL expression.
Gene_expression (expression) of RANKL
6) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
The RANKL expression level (Figure 2b) was significantly decreased with CS and with the combination of the two drugs.
Gene_expression (expression) of RANKL
7) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0
In human OA chondrocytes in culture, PGE(2) elicited a dose- and time-dependent increase in the synthesis of RANKL, the extent of which was greater than that of OPG.
Gene_expression (synthesis) of RANKL in chondrocytes
8) Confidence 0.77 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.14 Pain Relevance 0
RESULTS: In patients with OA, celecoxib decreased RANKL synthesis in the cartilage, thereby increasing the OPG:RANKL ratio.
Gene_expression (synthesis) of RANKL in cartilage
9) Confidence 0.77 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.15 Pain Relevance 0
We also used human OA chondrocytes to examine the effects of PGE(2) on OPG/RANKL synthesis, examining which surface receptors were affected by PGE(2).
Gene_expression (synthesis) of RANKL in chondrocytes
10) Confidence 0.77 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.16 Pain Relevance 0
The aim of this study was to examine whether nonsteroidal antiinflammatory drug (NSAID) treatment modulates the synthesis of OPG and RANKL in the cartilage of patients with OA, and to investigate whether prostaglandin E(2) (PGE(2)) modifies this system in human OA chondrocytes in culture.
Gene_expression (synthesis) of RANKL in cartilage associated with inflammation, cinod and osteoarthritis
11) Confidence 0.77 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20112374 Disease Relevance 0.63 Pain Relevance 0.33
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.
Gene_expression (synthesis) of RANKL in cartilage associated with inflammation, knee osteoarthritis and osteoarthritis
12) Confidence 0.77 Published 2010 Journal Arthritis Rheum. Section Title Doc Link 20112374 Disease Relevance 0.47 Pain Relevance 0.31
RESULTS: The expression of RANKL at mRNA and protein levels in HPDL cells was stimulated by IL-1beta.
Gene_expression (expression) of RANKL in HPDL
13) Confidence 0.76 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
In this study we investigate the effects of baicalin on RANKL protein production and messenger RNA (mRNA) expression induced by IL-1beta in cultured HPDL cells.
Gene_expression (production) of RANKL protein in HPDL
14) Confidence 0.76 Published 2006 Journal Pharmacology Section Abstract Doc Link 16636611 Disease Relevance 0.66 Pain Relevance 0.11
Baicalin suppressed IL-1beta-induced RANKL and COX-2 production at a concentration of 0.01 microg/ml.
Gene_expression (production) of RANKL
15) Confidence 0.76 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The data suggest that baicalin may inhibit RANKL mRNA expression via the suppression of COX-2 expression induced by IL-1beta.
Gene_expression (expression) of RANKL mRNA
16) Confidence 0.76 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
METHODS: To induce RANKL expression, IL-1beta was added to serum-free medium HPDL cells and incubated.
Gene_expression (expression) of RANKL in HPDL
17) Confidence 0.76 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms.
Spec (investigated) Gene_expression (expression) of RANKL associated with fibromyalgia
18) Confidence 0.72 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.73 Pain Relevance 0.15
In the patients with early rheumatoid arthritis (RA) treated with non-steroidal anti-inflammatory drugs alone, CD4+ T cells expressing both IFN-gamma and RANKL were detected by flow cytometry.
Gene_expression (expressing) of RANKL in T cells associated with inflammation, cinod and rheumatoid arthritis
19) Confidence 0.70 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16220542 Disease Relevance 0.36 Pain Relevance 0.23
The ratio of CD4+ T cells expressing both IFN-gamma and RANKL in total CD4+ T cells from PBMC was elevated in RA patients.
Gene_expression (expressing) of RANKL in T cells associated with rheumatoid arthritis
20) Confidence 0.70 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16220542 Disease Relevance 0.34 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox