INT130874

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 5.03
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17)
plasma membrane (ADAM17) cytoplasm (ADAM17)
Anatomy Link Frequency
sciatic nerves 4
ADAM17 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 100.00 Very High Very High Very High
Sciatic nerve 2 99.80 Very High Very High Very High
Neuritis 8 97.40 Very High Very High Very High
cytokine 2 94.08 High High
Peripheral nervous system 8 90.60 High High
Inflammation 6 88.12 High High
Chronic pancreatitis 2 64.92 Quite High
Demyelination 2 33.44 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 6 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 8 98.36 Very High Very High Very High
Syndrome 8 95.24 Very High Very High Very High
Polyradiculoneuropathy 2 93.84 High High
Demyelinating Disease 4 89.08 High High
INFLAMMATION 6 88.12 High High
Necrosis 8 83.52 Quite High
Disease 4 83.44 Quite High
Cancer 12 83.16 Quite High
Adenocarcinoma 12 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We explored the expression of TACE (ADAM-17) in sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an animal model of the Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy.
Negative_regulation (explored) of Gene_expression (expression) of TACE in sciatic nerves associated with polyradiculoneuropathy, syndrome, experimental autoimmune neuritis, metalloproteinase, sciatic nerve and neuritis
1) Confidence 0.43 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.33 Pain Relevance 0.78
We explored the expression of TACE (ADAM-17) in sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an animal model of the Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy.
Negative_regulation (explored) of Gene_expression (expression) of ADAM-17 in sciatic nerves associated with polyradiculoneuropathy, syndrome, experimental autoimmune neuritis, metalloproteinase, sciatic nerve and neuritis
2) Confidence 0.43 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.33 Pain Relevance 0.78
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Negative_regulation (down-regulated) of Gene_expression (expression) of ADAM17 associated with pancreatic cancer
3) Confidence 0.41 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.19 Pain Relevance 0.10
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Negative_regulation (down-regulated) of Gene_expression (expression) of TACE associated with pancreatic cancer
4) Confidence 0.41 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.18 Pain Relevance 0.10

General Comments

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