INT130875

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 15.46
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17)
plasma membrane (ADAM17) cytoplasm (ADAM17)
Anatomy Link Frequency
sciatic nerves 2
peripheral nervous system 2
T cells 2
cartilage 1
ADAM17 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 164 100.00 Very High Very High Very High
Neuritis 24 100.00 Very High Very High Very High
Sciatic nerve 6 99.80 Very High Very High Very High
Peripheral nervous system 24 99.32 Very High Very High Very High
Inflammation 32 97.04 Very High Very High Very High
Demyelination 6 96.52 Very High Very High Very High
cytokine 18 93.56 High High
Chronic pancreatitis 6 79.24 Quite High
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Osteoarthritis 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 56 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 24 100.00 Very High Very High Very High
Pancreatic Cancer 18 99.52 Very High Very High Very High
Syndrome 24 99.44 Very High Very High Very High
Disease 40 98.88 Very High Very High Very High
Adenocarcinoma 36 98.20 Very High Very High Very High
INFLAMMATION 34 97.04 Very High Very High Very High
Demyelinating Disease 12 96.52 Very High Very High Very High
Polyradiculoneuropathy 6 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We explored the expression of TACE (ADAM-17) in sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an animal model of the Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy.
Gene_expression (expression) of TACE in sciatic nerves associated with polyradiculoneuropathy, syndrome, experimental autoimmune neuritis, metalloproteinase, sciatic nerve and neuritis
1) Confidence 0.78 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.32 Pain Relevance 0.78
We explored the expression of TACE (ADAM-17) in sciatic nerves from Lewis rats with experimental autoimmune neuritis (EAN), an animal model of the Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy.
Gene_expression (expression) of ADAM-17 in sciatic nerves associated with polyradiculoneuropathy, syndrome, experimental autoimmune neuritis, metalloproteinase, sciatic nerve and neuritis
2) Confidence 0.78 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.33 Pain Relevance 0.78
Tumor necrosis factor-alpha-converting enzyme is expressed in the inflamed peripheral nervous system.
Gene_expression (expressed) of Tumor necrosis factor-alpha-converting enzyme in peripheral nervous system associated with necrosis, peripheral nervous system and cancer
3) Confidence 0.78 Published 2005 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 16221290 Disease Relevance 1.34 Pain Relevance 0.78
Western blot, flow cytometry, and confocal microscopy analyses showed the aberrant expression of ADAM17/TACE protein in pancreatic cancer cell lines.
Gene_expression (expression) of ADAM17 associated with pancreatic cancer
4) Confidence 0.75 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.33 Pain Relevance 0.15
In conclusion, our findings provide evidence of aberrant expression of the proteolytically active ADAM17/TACE in advanced precursor lesions (PanIN-3) and PDAC while identifying its critical involvement in the invasion process.
Gene_expression (expression) of ADAM17 associated with adenocarcinoma
5) Confidence 0.75 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 0.94 Pain Relevance 0.09
Western blot, flow cytometry, and confocal microscopy analyses showed the aberrant expression of ADAM17/TACE protein in pancreatic cancer cell lines.
Gene_expression (expression) of TACE associated with pancreatic cancer
6) Confidence 0.75 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.33 Pain Relevance 0.15
Our findings indicate that ADAM-17 is upregulated during EAN and expressed in nerves of GBS patients and thus may contribute to the pathogenesis of inflammatory demyelination of the PNS.
Gene_expression (expressed) of ADAM-17 in PNS associated with demyelination, peripheral nervous system, inflammation, syndrome, metalloproteinase and neuritis
7) Confidence 0.68 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.59 Pain Relevance 0.97
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Gene_expression (expression) of TACE associated with pancreatic cancer
8) Confidence 0.65 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.18 Pain Relevance 0.10
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Gene_expression (expression) of ADAM17 associated with pancreatic cancer
9) Confidence 0.65 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.19 Pain Relevance 0.10
In EAN, T lymphocytes could be defined as the cellular source of ADAM-17 with peak expression levels at maximum clinical disease severity.
Gene_expression (expression) of ADAM-17 in T lymphocytes associated with metalloproteinase, disease and neuritis
10) Confidence 0.59 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.42 Pain Relevance 0.98
Similarly, in human sural nerves, ADAM-17-expressing T cells could be localized primarily within the epi- and perineurium, whereas in control sections from patients with non-inflammatory neuropathies, no expression could be depicted.
Gene_expression (expressing) of ADAM-17-expressing in T cells associated with inflammation and metalloproteinase
11) Confidence 0.59 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.39 Pain Relevance 0.98
In conclusion, our findings provide evidence of aberrant expression of the proteolytically active ADAM17/TACE in advanced precursor lesions (PanIN-3) and PDAC while identifying its critical involvement in the invasion process.
Gene_expression (expression) of TACE associated with adenocarcinoma
12) Confidence 0.58 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 0.94 Pain Relevance 0.09
ADAM-17 is known for its ability to release TNF?
Gene_expression (known) of ADAM-17
13) Confidence 0.13 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0 Pain Relevance 0.29
ADAMTS-4 and ADAMTS-5 cleave proteoglycan [95], and ADAM-10, ADAM-12, ADAM-15 and ADAM-17 are also found in cartilage.
Gene_expression (found) of ADAM-17 in cartilage
14) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.17 Pain Relevance 0.17

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