INT1309

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 152
Total Number 158
Disease Relevance 24.25
Pain Relevance 81.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
brain 10
anterior pituitary 10
pituitary 8
neurons 8
fat 5
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 301 100.00 Very High Very High Very High
Morphine 214 100.00 Very High Very High Very High
agonist 159 100.00 Very High Very High Very High
narcan 134 100.00 Very High Very High Very High
opiate 82 100.00 Very High Very High Very High
Somatostatin 58 100.00 Very High Very High Very High
Opioid 53 100.00 Very High Very High Very High
Serotonin 51 100.00 Very High Very High Very High
Nicotine 10 100.00 Very High Very High Very High
MU agonist 7 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 10 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 14 99.92 Very High Very High Very High
Impaired Glucose Tolerance 8 99.92 Very High Very High Very High
Xerostomia 1 99.90 Very High Very High Very High
Pituitary Cancer 10 99.88 Very High Very High Very High
Syndrome 4 99.78 Very High Very High Very High
Chronic Disease 2 99.74 Very High Very High Very High
Hydrocephalus 3 99.68 Very High Very High Very High
Acromegaly 15 99.64 Very High Very High Very High
Pain 35 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional subsensitivity of 5-hydroxytryptamine1C or alpha 2 adrenergic heteroreceptors mediating clonidine-induced growth hormone release in the Fawn-Hooded rat strain relative to the Wistar rat strain.
Positive_regulation (induced) of Localization (release) of growth hormone associated with sprains and strains and clonidine
1) Confidence 0.69 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1356149 Disease Relevance 0.25 Pain Relevance 1.02
However, there is increasing appreciation that suboptimal growth hormone secretion, leading to a state of adult growth hormone deficiency, may occur in the setting of chronic inflammatory disease, chronic corticosteroid use, and fibromyalgia.
Positive_regulation (leading) of Localization (secretion) of growth hormone associated with corticosteroid, inflammation, disease, growth hormone deficiency and fibrositis
2) Confidence 0.67 Published 2005 Journal Curr Pain Headache Rep Section Abstract Doc Link 16157062 Disease Relevance 0.65 Pain Relevance 0.22
However, there is increasing appreciation that suboptimal growth hormone secretion, leading to a state of adult growth hormone deficiency, may occur in the setting of chronic inflammatory disease, chronic corticosteroid use, and fibromyalgia.
Positive_regulation (leading) of Localization (secretion) of growth hormone associated with corticosteroid, inflammation, disease, growth hormone deficiency and fibrositis
3) Confidence 0.67 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15251074 Disease Relevance 0.65 Pain Relevance 0.22
Evidently, adrenergic mechanisms are involved in the morphine-induced stimulation of growth hormone secretion, but not in the morphine-induced stimulation of prolactin secretion.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone associated with morphine
4) Confidence 0.66 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.26
The enhanced secretion of both growth hormone and prolactin was antagonized by atipamezole (an alpha 2-adrenoceptor antagonist) but not by prazosin (an alpha 1-adrenoceptor antagonist).
Positive_regulation (enhanced) of Localization (secretion) of growth hormone associated with antagonist
5) Confidence 0.66 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.11
It was recently introduced in the health-food market as a food supplement for body builders with claims of anabolic effects by stimulating growth hormone release.
Positive_regulation (stimulating) of Localization (release) of growth hormone in body
6) Confidence 0.66 Published 1991 Journal Am J Emerg Med Section Abstract Doc Link 2054002 Disease Relevance 0.33 Pain Relevance 0.09
We have observed 4 cases of hypoglycemia associated with clonidine stimulation of growth hormone secretion; only one patient had growth hormone deficiency.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone associated with hypoglycemia, growth hormone deficiency and clonidine
7) Confidence 0.66 Published 2001 Journal J. Pediatr. Section Abstract Doc Link 11487765 Disease Relevance 0.44 Pain Relevance 0.27
In contrast to the reported effects of clonidine in healthy subjects, clonidine did not significantly increase growth hormone secretion in the depressed patients before treatment.
Neg (not) Positive_regulation (increase) of Localization (secretion) of growth hormone associated with clonidine
8) Confidence 0.66 Published 1982 Journal Psychiatry Res Section Abstract Doc Link 6959166 Disease Relevance 0 Pain Relevance 0.64
These findings suggest that development of functional subsensitivity of either alpha 2-adrenergic heteroreceptors or 5-HT1C receptors mediating clonidine-induced growth hormone secretion following chronic treatment with glucocorticoids and 5-HT uptake inhibitors.
Positive_regulation (induced) of Localization (secretion) of growth hormone associated with clonidine
9) Confidence 0.66 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.75
After the 6-h lag time, tolerance manifested to the thermal, locomotor depressant and hormonal (stimulation of growth hormone and prolactin secretion) effects of morphine.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone associated with tolerance and morphine
10) Confidence 0.64 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8846813 Disease Relevance 0 Pain Relevance 1.05
Clonidine, an alpha-agonist which penetrates the brain, increased plasma growth hormone secretion.
Positive_regulation (increased) of Localization (secretion) of plasma growth hormone in brain associated with agonist and clonidine
11) Confidence 0.62 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.34
Pharmacological evidence for stimulation of growth hormone secretion by a central noradrenergic system in dogs.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone
12) Confidence 0.62 Published 1976 Journal Neuroscience Section Title Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.30
These findings suggest that clonidine stimulates growth hormone secretion by activation of alpha 2 adrenergic heteroreceptors present on 5-HT nerve terminals which, in turn, enhance 5-HT activity via stimulation of postsynaptic 5-HT1C receptors to promote growth hormone releasing factor.
Positive_regulation (stimulates) of Localization (secretion) of growth hormone in nerve associated with clonidine
13) Confidence 0.60 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.34 Pain Relevance 1.12
The lack of effect indicates that an opioid pathway is not involved in exercise-induced growth hormone and prolactin release in humans, in contrast to that in rats.
Positive_regulation (induced) of Localization (release) of growth hormone associated with opioid
14) Confidence 0.58 Published 1980 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 7226565 Disease Relevance 0 Pain Relevance 0.23
Failure of naloxone to alter exercise-induced growth hormone and prolactin release in normal men.
Positive_regulation (induced) of Localization (release) of growth hormone associated with narcan
15) Confidence 0.58 Published 1980 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 7226565 Disease Relevance 0 Pain Relevance 0.28
Alpha 2-adrenergic receptors mediate adrenergic stimulation of growth hormone (GH) secretion in the rat.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone
16) Confidence 0.58 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3104956 Disease Relevance 0 Pain Relevance 0.40
Morphine sulfate caused growth hormone release in rats pretreated with alpha-methyl-p-tryosine, a catecholamine synthesis inhibitor.
Positive_regulation (caused) of Localization (release) of growth hormone associated with catecholamine and morphine
17) Confidence 0.56 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247214 Disease Relevance 0 Pain Relevance 1.81
Most of the children had a modified response of growth hormone secretion subsequent to the various stimulation tests.
Positive_regulation (response) of Localization (secretion) of growth hormone
18) Confidence 0.49 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.22 Pain Relevance 0.31
We studied the response of growth hormone secretion after the administration of L-dopa, clonidine, and growth hormone releasing hormone in eight growth-retarded children with Down syndrome aged 1 to 6.5 years.
Positive_regulation (response) of Localization (secretion) of growth hormone associated with down syndrome and clonidine
19) Confidence 0.49 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.17 Pain Relevance 0.25
The stimulation of alpha 2-adrenoceptor enhances secretion of both growth hormone and prolactin.
Positive_regulation (enhances) of Localization (secretion) of growth hormone
20) Confidence 0.48 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.33

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