INT130906

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 2.41
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ureter 1
bladder 1
intestine 1
P2RX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Visceral pain 3 97.94 Very High Very High Very High
Pain 15 96.24 Very High Very High Very High
Spinal cord 3 80.00 Quite High
Analgesic 9 75.00 Quite High
allodynia 3 74.24 Quite High
adenocard 3 73.52 Quite High
Kinase C 6 71.68 Quite High
Neuropathic pain 3 69.12 Quite High
Inflammation 6 67.44 Quite High
Acute pain 3 65.52 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 97.94 Very High Very High Very High
Pain 15 96.24 Very High Very High Very High
Nociception 6 82.80 Quite High
Neuropathic Pain 6 74.24 Quite High
INFLAMMATION 3 67.44 Quite High
Shock 3 43.36 Quite Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Spec (possibly) Regulation (acts) of P2X2 in bladder associated with pain and visceral pain
1) Confidence 0.26 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.70 Pain Relevance 0.85
In contrast, ATP-evoked P2X2-4 receptor currents were unaffected by lipid raft disruption.
Neg (unaffected) Regulation (unaffected) of P2X2
2) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Spec (possibly) Regulation (acts) of P2X2 in ureter associated with pain and visceral pain
3) Confidence 0.09 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.70 Pain Relevance 0.85
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Spec (possibly) Regulation (acts) of P2X2 in intestine associated with pain and visceral pain
4) Confidence 0.09 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.70 Pain Relevance 0.85
P2X2-4 receptors have been shown to be regulated by second messenger pathways (31–33).
Regulation (regulated) of P2X2
5) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Raft association can help organize signaling complexes, and it remains to be determined if localization to rafts is essential for the regulation of P2X2-4 receptors.
Regulation (regulation) of P2X2
6) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0

General Comments

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