INT130926

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 10.18
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
cell-cell signaling (TNFSF10)
Anatomy Link Frequency
macrophages 2
colon 1
T cells 1
neutrophils 1
TNFSF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 100.00 Very High Very High Very High
Arthritis 70 99.40 Very High Very High Very High
cINOD 8 97.40 Very High Very High Very High
rheumatoid arthritis 147 92.80 High High
cytokine 52 86.60 High High
antagonist 6 83.92 Quite High
Osteoarthritis 26 73.56 Quite High
Inflammation 128 70.76 Quite High
cva 1 50.36 Quite High
Pain 3 42.08 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 380 100.00 Very High Very High Very High
Cancer 278 99.92 Very High Very High Very High
Necrosis 33 99.68 Very High Very High Very High
Colon Cancer 92 99.60 Very High Very High Very High
Death 71 99.44 Very High Very High Very High
Arthritis 36 99.40 Very High Very High Very High
Autoimmune Disease 15 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.06 Very High Very High Very High
INFLAMMATION 127 96.68 Very High Very High Very High
Diabetes Mellitus 84 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other TRAIL receptors such as TRAIL-R3 and TRAIL-R4 [4] act as decoy receptors that are able to inhibit the cytotoxic effects of TRAIL.
Negative_regulation (inhibit) of TRAIL
1) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.21 Pain Relevance 0.19
Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.
Negative_regulation (inhibitor) of TRAIL in colon associated with colon cancer and apoptosis
2) Confidence 0.36 Published 2005 Journal Mol. Cancer Ther. Section Title Doc Link 16227396 Disease Relevance 1.22 Pain Relevance 0.19
Like CD95L, TRAIL has been reported to be a potent inhibitor of autoimmune arthritis [24].
Negative_regulation (inhibitor) of TRAIL associated with arthritis
3) Confidence 0.34 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.23 Pain Relevance 0.14
Thus, Egr-1 upregulation, which is frequently observed in atherosclerosis, is likely to be involved in insulin-mediated TRAIL downregulation [70].
Negative_regulation (downregulation) of TRAIL associated with increased venous pressure under development
4) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.97 Pain Relevance 0.05
failed to inhibit TRAIL induced apoptosis in Snail deficient HCT116 or Hke-3 cells (Fig. 8A), confirming that macrophages and IL-1?
Negative_regulation (inhibit) of TRAIL in macrophages associated with apoptosis
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.07 Pain Relevance 0.03
Peripheral blood monocytes inhibited TRAIL-induced apoptosis also in 293T cells (Fig. 2D), demonstrating that macrophage-derived factors are general and potent inhibitors of TRAIL-induced cell death.


Negative_regulation (inhibitors) of TRAIL in macrophage associated with apoptosis and death
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.21 Pain Relevance 0
, TRAIL (TNF-related apoptosis inducing ligand), IL-1, matrix metalloproteinase (MMP)-9, calcium and phosphate ions, NO, ceramide, retinoic acid, or serum deprivation and mechanical forces [150,154,159].
Negative_regulation (deprivation) of TRAIL associated with metalloproteinase and apoptosis
7) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 1.43 Pain Relevance 0.19
The effect of IL-4 on neutrophil expression of OPG, however, could be associated with the anti-apoptotic function of IL-4 through OPG inhibition of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) produced by human neutrophils [35,36].
Negative_regulation (inhibition) of TRAIL in neutrophils associated with necrosis, cancer and apoptosis
8) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.73 Pain Relevance 0.22
These T cells are unusually resistant to apoptosis in SF that contains a significant amount of pro-apoptotic factors such as bioactive FasL, TRAIL and TNF-?
Negative_regulation (amount) of TRAIL in T cells associated with apoptosis
9) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.12 Pain Relevance 0.29

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