INT130927

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 3.72
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
band 2
TK6 2
HFL1 1
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 10 89.44 High High
Inflammation 98 88.08 High High
agonist 8 46.08 Quite Low
Glutamate receptor 5 38.52 Quite Low
cytokine 30 33.52 Quite Low
Inflammatory response 10 12.80 Low Low
chemokine 7 5.28 Low Low
anesthesia 15 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 390 100.00 Very High Very High Very High
Malignant Neoplastic Disease 5 98.92 Very High Very High Very High
Polyps 1 97.12 Very High Very High Very High
Corneal Neovascularization 14 93.04 High High
INFLAMMATION 106 88.08 High High
Repression 5 86.20 High High
Metastasis 35 85.96 High High
Sarcoma 14 82.40 Quite High
Thrombosis 30 78.48 Quite High
Dyslipidemia /

Combined Dyslipidemia

2 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adding MPB before shear partially prevented the loss of TSP-1 protein (Fig. 3E), as did the other thiol-reactive reagents BMCC (Fig. 3F) and N-ethylmaleimide (NEM) (Fig. 3G).
Negative_regulation (loss) of TSP-1 protein
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
1 activation after 1 hour of stirring, we hypothesized that this plateau may be due to TSP-1 depletion.
Negative_regulation (depletion) of TSP-1
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Thus, shear-dependent loss of TSP-1 appears to require free thiols.


Negative_regulation (loss) of TSP-1
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Replenishing TSP-1 after stirring-induced depletion enhances TGF-?
Negative_regulation (Replenishing) of TSP-1
4) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Densitometric quantitation of TSP-1 bands from three independent experiments showed that adding NEM before shear reduced TSP-1 protein depletion during shear by approximately 50% (data not shown).
Negative_regulation (depletion) of TSP-1 protein in bands
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Moreover, we found that TSP-1 becomes depleted from WT samples during stirring or shear, and that replenishing TSP-1 during stirring enhances the activation of TGF-?
Negative_regulation (replenishing) of TSP-1
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0.15 Pain Relevance 0
In fact, we found that replenishing TSP-1 during stirring results in a further increase in the TGF-?
Negative_regulation (replenishing) of TSP-1
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
TSP-1 depletion was nearly complete within 1 hour (Fig. 3D center panel), and was greater than the partial depletions of the Mr 25 kD TGF-?
Negative_regulation (depletion) of TSP-1
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
We found a time-dependent loss of TSP-1 protein as judged by immunoblot analysis (Fig. 3D, center panel), which could fully account for the reduction in thiol-labeling at the expected Mr of the TSP-1 band (Fig. 3D, left panel).
Negative_regulation (loss) of TSP-1 protein in band
9) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Since we observed both depletion of TSP-1 and a plateau of TGF-?
Negative_regulation (depletion) of TSP-1
10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
KO mice was partially reversed by inactivation of TSP-1 function (Figure 5E).
Negative_regulation (inactivation) of TSP-1
11) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.90 Pain Relevance 0.04
This is the first report suggesting that COX inhibitors suppress tumor cell invasion via TSP-1, which occurs downstream of Egr-1.
Negative_regulation (suppress) of TSP-1 associated with cancer
12) Confidence 0.38 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.52 Pain Relevance 0.23
When TSP-1 was depleted by neutralizing antibody in PPAR?
Negative_regulation (depleted) of TSP-1
13) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.80 Pain Relevance 0.09
consistent with those of others showing THBS1 to be downregulated by ultraviolet
Negative_regulation (downregulated) of THBS1
14) Confidence 0.24 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.09 Pain Relevance 0
THBS1 was downregulated in irradiated TK6 and HFL1 cells. vWF was induced in radiation-exposed HeLa cells, but its expression was downregulated in Jurkat cells.
Negative_regulation (downregulated) of THBS1 in TK6
15) Confidence 0.24 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
THBS1 gene was first repressed and later returned to normal levels at 12-hour time
Negative_regulation (repressed) of THBS1 gene
16) Confidence 0.24 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.14 Pain Relevance 0
of THBS1 was found to be downregulated in irradiated TK6 (Figure 2) and
Negative_regulation (downregulated) of THBS1 in TK6
17) Confidence 0.24 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
THBS1 was downregulated in irradiated TK6 and HFL1 cells. vWF was induced in radiation-exposed HeLa cells, but its expression was downregulated in Jurkat cells.
Negative_regulation (downregulated) of THBS1 in HFL1
18) Confidence 0.08 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Negative_regulation (decrease) of TSP-1 associated with malignant neoplastic disease
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.83 Pain Relevance 0

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