INT130928

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.62
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
granulocyte 4
platelet 2
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 138 99.32 Very High Very High Very High
cytokine 24 97.20 Very High Very High Very High
cINOD 5 95.52 Very High Very High Very High
Bioavailability 2 80.24 Quite High
Inflammatory response 15 74.96 Quite High
chemokine 6 70.32 Quite High
agonist 12 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 661 99.78 Very High Very High Very High
INFLAMMATION 153 99.32 Very High Very High Very High
Polyps 1 98.76 Very High Very High Very High
Reprotox - General 1 3 95.88 Very High Very High Very High
Sarcoma 2 89.76 High High
Lymphatic System Cancer 1 88.92 High High
Lung Cancer 1 88.08 High High
Renal Cancer 8 86.60 High High
Myeloid Leukemia 1 80.16 Quite High
Metastasis 42 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of Min mice with concentrations of sulindac sulfide that inhibit tumor formation increased the expression of Egr-1 and TSP-1 in colonic tissues and in the polyps of these mice.
Positive_regulation (increased) of Gene_expression (expression) of TSP-1 associated with cancer and polyps
1) Confidence 0.62 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.54 Pain Relevance 0.25
deficiency suppresses tumor growth by increasing the expression of the matrix protein thrombospondin-1 (TSP-1) which inhibits angiogenesis and stimulates granulocyte migration [28].
Positive_regulation (increasing) of Gene_expression (expression) of thrombospondin-1 in granulocyte associated with cancer
2) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.57 Pain Relevance 0.29
It is of interest to consider why the TSP-1 contribution to activation of TGF-?
Positive_regulation (why) of Gene_expression (contribution) of TSP-1
3) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Our data indicate that under conditions of optimal stirring and shear, the presence of TSP-1 at levels found in serum and platelet releasates enhances TGF-?
Positive_regulation (enhances) of Gene_expression (presence) of TSP-1 in platelet
4) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
The TSP-1 contribution in serum increases active TGF-?
Positive_regulation (increases) of Gene_expression (contribution) of TSP-1
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
It is of interest to consider why the TSP-1 contribution to activation of TGF-?
Positive_regulation (activation) of Gene_expression (contribution) of TSP-1
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
deficiency suppresses tumor growth by increasing the expression of the matrix protein thrombospondin-1 (TSP-1) which inhibits angiogenesis and stimulates granulocyte migration [28].
Positive_regulation (increasing) of Gene_expression (expression) of TSP-1 in granulocyte associated with cancer
7) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.57 Pain Relevance 0.29
deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth.
Positive_regulation (excess) of Gene_expression (production) of thrombospondin-1 associated with inflammation and cancer
8) Confidence 0.34 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1800345 Disease Relevance 1.19 Pain Relevance 0.22
However, the TSP-1 overexpressing construct inhibited growth of DU-145 xenografts in Balb/c mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TSP-1
9) Confidence 0.28 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.53 Pain Relevance 0.04
mice can be rescued with addition of TSP-1 and TSP-2, both potent activators of TGF-?
Positive_regulation (activators) of Gene_expression (addition) of TSP-1
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.21 Pain Relevance 0

General Comments

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