INT130940

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.12
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CSE (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 31 96.72 Very High Very High Very High
nud 22 50.00 Quite Low
Inflammation 12 50.00 Quite Low
Action potential 10 29.20 Quite Low
aspirin 2 10.00 Low Low
spastic colon 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Visceral pain 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 31 96.72 Very High Very High Very High
Death 1 85.04 High High
Diabetes Mellitus 11 79.60 Quite High
Body Weight 7 65.32 Quite High
INFLAMMATION 14 56.56 Quite High
Dyspepsia 22 50.00 Quite Low
Injury 4 50.00 Quite Low
Necrosis 1 46.16 Quite Low
Nociception 6 37.44 Quite Low
Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to NSAIDs inhibits Sp1 binding to its promoter and abrogates CSE expression in HEK-293 cells transfected with a vector containing the core CSE promoter.
Negative_regulation (abrogates) of Gene_expression (expression) of CSE
1) Confidence 0.20 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0 Pain Relevance 0
Exposure to NSAIDs reduced H(2)S formation and CSE expression (mRNA and protein) and activity by 60%-70%.
Negative_regulation (reduced) of Gene_expression (expression) of CSE
2) Confidence 0.20 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0.06 Pain Relevance 0
It is possible that CSE could aid in releasing of insulin from the surviving ?
Spec (possible) Negative_regulation (possible) of Gene_expression (aid) of CSE
3) Confidence 0.13 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.52 Pain Relevance 0
The expression of the other H2S producing enzyme CSE was also determined.
Spec (determined) Negative_regulation (determined) of Gene_expression (producing) of CSE
4) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.54 Pain Relevance 0.27

General Comments

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