INT130943

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r) extracellular region (Il6r) enzyme binding (Il6r)
Anatomy Link Frequency
arcuate nucleus 1
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 24 94.68 High High
cytokine 10 94.24 High High
Inflammation 6 75.00 Quite High
anesthesia 4 67.76 Quite High
dexamethasone 5 63.60 Quite High
Inflammatory response 1 45.28 Quite Low
Intracerebroventricular 5 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 14 76.96 Quite High
INFLAMMATION 5 75.00 Quite High
Necrosis 1 65.56 Quite High
Cancer 1 65.20 Quite High
Insulin Resistance 20 50.00 Quite Low
Obesity 40 5.00 Very Low Very Low Very Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The equation describing the up-regulation of IL-6 receptor type 1 mRNA (IL6R1m) time profile following MPL treatment is:
Regulation (regulation) of IL6R1m
1) Confidence 0.40 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
The immunoreactivity of IL-6R and pp70S6K was not detected in the hypothalamic arcuate nucleus of rats after i.c.v. saline infusion.
Regulation (immunoreactivity) of IL-6R in arcuate nucleus
2) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.15 Pain Relevance 0
Hemofiltration is effective in removal of TNF-alpha, but its role is debatable for the control of IL-1, IL-6, sIL-6r and IL-8 levels.
Regulation (control) of sIL-6r
3) Confidence 0.00 Published 2005 Journal Perfusion Section Abstract Doc Link 16231622 Disease Relevance 0.21 Pain Relevance 0.25

General Comments

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