INT13095

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.69
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga) molecular_function (Cga) cellular_component (Cga)
biological_process (Cga)
Anatomy Link Frequency
pituitary 4
follicle 2
tail 2
posterior pituitary 2
anterior pituitary 2
Cga (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
Clonidine 6 99.98 Very High Very High Very High
opiate 4 99.82 Very High Very High Very High
narcan 2 99.82 Very High Very High Very High
tail-flick 1 99.80 Very High Very High Very High
agonist 4 97.96 Very High Very High Very High
Opioid 4 96.04 Very High Very High Very High
Buprenorphine 5 95.44 Very High Very High Very High
cocaine 9 94.44 High High
MU agonist 1 91.00 High High
Disease Link Frequency Relevance Heat
Shock 4 99.98 Very High Very High Very High
Stress 5 91.96 High High
Opiate Addiction 1 56.04 Quite High
Hyperalgesia 1 52.80 Quite High
Depression 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That is, exposure to either isolation or to shock increased both pituitary-adrenal hormone secretion and tail-flick latencies but only administration of shock potentiated freezing and ultrasonic vocalizations.
Positive_regulation (increased) of Localization (secretion) of pituitary-adrenal hormone in tail associated with shock and tail-flick
1) Confidence 0.69 Published 1991 Journal Dev Psychobiol Section Abstract Doc Link 1661243 Disease Relevance 0.63 Pain Relevance 0.11
Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.
Positive_regulation (induced) of Localization (release) of pituitary hormone in posterior pituitary associated with narcan and enkephalin
2) Confidence 0.67 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7700499 Disease Relevance 0.06 Pain Relevance 1.00
The results provide support for the role of multiple opiate receptors in opiate-induced changes in anterior pituitary hormone release.
Positive_regulation (changes) of Localization (release) of pituitary hormone in anterior pituitary associated with opiate
3) Confidence 0.49 Published 1985 Journal Life Sci. Section Abstract Doc Link 2997571 Disease Relevance 0 Pain Relevance 0.86
Reduced food intake results in altered reproductive function in female mammals and previous studies have shown this to be due, at least in part, to an increase in the negative feedback efficacy of estrogen on pituitary luteinizing hormone (LH) secretion.
Positive_regulation (increase) of Localization (secretion) of pituitary luteinizing hormone in pituitary
4) Confidence 0.23 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 2041586 Disease Relevance 0 Pain Relevance 0.05
Previous findings show that clonidine increases pituitary growth hormone (GH) secretion by a central mechanism involving postsynaptic alpha2-adrenergic receptors.
Positive_regulation (increases) of Localization (secretion) of pituitary growth hormone in pituitary associated with clonidine
5) Confidence 0.13 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099682 Disease Relevance 0 Pain Relevance 0.79
Basal and K(+)-induced release of GnRH from SME, and pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) did not differ among groups (P greater than .05).
Positive_regulation (-induced) of Localization (release) of pituitary luteinizing hormone in follicle
6) Confidence 0.01 Published 1990 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 2143972 Disease Relevance 0 Pain Relevance 0.15

General Comments

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