INT13096

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga) molecular_function (Cga) cellular_component (Cga)
biological_process (Cga)
Anatomy Link Frequency
plasma 1
follicle 1
gonadal 1
Cga (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1 96.32 Very High Very High Very High
Analgesic 2 95.96 Very High Very High Very High
antagonist 2 95.96 Very High Very High Very High
opiate 1 95.52 Very High Very High Very High
Endogenous opioid 1 92.92 High High
endometriosis 1 70.56 Quite High
tail-flick 1 70.16 Quite High
Dismenorea 1 65.20 Quite High
Intracerebroventricular 1 49.92 Quite Low
Disease Link Frequency Relevance Heat
Stress 9 99.56 Very High Very High Very High
Hyperalgesia 1 93.64 High High
Shock 4 84.60 Quite High
Disease 1 78.32 Quite High
Reprotox - General 1 2 71.92 Quite High
Endometriosis (extended) 1 70.56 Quite High
Myoma 1 68.72 Quite High
Polycystic Ovary Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although in Days 7 and 14 rats exposure to the two stress conditions produced significant elevations in pituitary-adrenal hormone concentrations, plasma levels were lower than those measured in Day 21 rats.
Positive_regulation (elevations) of pituitary-adrenal hormone in plasma associated with stress
1) Confidence 0.69 Published 1991 Journal Dev Psychobiol Section Abstract Doc Link 1661243 Disease Relevance 0.70 Pain Relevance 0.22
An alternative explanation is that ip ethanol injection might stress rats sufficiently to activate hypothalamic-pituitary-adrenocortical (H-P-A) and EOP systems that are well known to inhibit hormonal activities of the hypothalamic-pituitary-gonadal (H-P-G) axis.
Positive_regulation (activate) of hypothalamic-pituitary-adrenocortical in gonadal associated with stress
2) Confidence 0.03 Published 1987 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 3426730 Disease Relevance 0.24 Pain Relevance 0.28
Chronic administration of the GnRH analogues nafarelin acetate and leuprolide acetate results in an initial stimulation of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which is followed by a profound decrease in the secretion of LH and FSH.
Positive_regulation (stimulation) of pituitary luteinizing hormone in follicle
3) Confidence 0.00 Published 1992 Journal Trends Endocrinol. Metab. Section Abstract Doc Link 18407075 Disease Relevance 0.29 Pain Relevance 0.10

General Comments

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