INT130961

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.03
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MADCAM1) aging (MADCAM1) cell adhesion (MADCAM1)
plasma membrane (MADCAM1) embryo development (MADCAM1)
Anatomy Link Frequency
lymphoid tissue 1
ascending colon 1
MADCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 256 99.00 Very High Very High Very High
Multiple sclerosis 10 91.04 High High
Inflammation 104 85.16 High High
Central nervous system 6 82.32 Quite High
cytokine 30 80.24 Quite High
ischemia 32 65.64 Quite High
Inflammatory response 19 61.72 Quite High
Inflammatory marker 4 48.80 Quite Low
chemokine 3 26.92 Quite Low
abdominal pain 8 11.08 Low Low
Disease Link Frequency Relevance Heat
Adhesions 27 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

251 99.00 Very High Very High Very High
Inflammatory Bowel Disease 27 98.88 Very High Very High Very High
Disease 59 97.20 Very High Very High Very High
Encephalitis 4 94.40 High High
Demyelinating Disease 10 91.04 High High
Colitis 6 90.96 High High
Reperfusion Injury 3 89.92 High High
INFLAMMATION 120 85.16 High High
Urological Neuroanatomy 11 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only 3 patient samples demonstrated sporadic and minimal expression of E-selectin (data not shown), ICAM-1 and MADCAM-1 (Fig. 4) following maximal reperfusion.


Gene_expression (expression) of MADCAM-1
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.38 Pain Relevance 0.11
MAdCAM-1 is selectively expressed in venules in the gut and gut-associated lymphoid tissue (Butcher and Picker 1996) (Figure 2).
Gene_expression (expressed) of MAdCAM-1 in lymphoid tissue
2) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721358 Disease Relevance 1.56 Pain Relevance 0.36
7, while colonic biopsies were examined for endothelial expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), in samples taken from IBS patients (60% D-IBS), ulcerative colitis patients and asymptomatic patients with a negative colonoscopy for other indications.
Spec (examined) Gene_expression (expression) of MAdCAM-1 associated with inflammatory bowel disease, spastic colon and adhesions
3) Confidence 0.21 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 0.37 Pain Relevance 0.72
7 which mediates homing to intestinal mucosa by binding to its endothelial expressed ligand MAdCAM-1.
Gene_expression (expressed) of MAdCAM-1
4) Confidence 0.21 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 0.53 Pain Relevance 0.57
7 and MAdCAM-1 resembling that seen in patients with ulcerative colitis.
Gene_expression (resembling) of MAdCAM-1 associated with inflammatory bowel disease
5) Confidence 0.18 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 0.56 Pain Relevance 0.52
The frequency of intestinal T cells expressing integrin beta7+ was unaltered in IBS and UC patients, although the expression of mucosal addressin cell adhesion molecule-1+ endothelium, the ligand for integrin beta7, was increased in the ascending colon of IBS and UC patients as compared with control subjects.
Gene_expression (expression) of addressin cell adhesion molecule-1 in ascending colon
6) Confidence 0.09 Published 2005 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 16234043 Disease Relevance 0 Pain Relevance 0

General Comments

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