INT130971

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 0.32
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3r1) nucleus (Slc9a3r1) cytoplasm (Slc9a3r1)
Anatomy Link Frequency
lateral 1
band 1
basal cell 1
Slc9a3r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1 92.72 High High
Root ganglion neuron 1 88.72 High High
Kinase C 1 81.20 Quite High
Mechanosensation 2 79.08 Quite High
Pain 1 77.04 Quite High
Peripheral nervous system 1 75.84 Quite High
anesthesia 30 74.64 Quite High
ASIC 1 70.60 Quite High
nociceptor 2 69.92 Quite High
ketamine 20 67.56 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 92.72 High High
Pain 1 77.04 Quite High
Hypothermia 20 60.80 Quite High
Injury 30 31.84 Quite Low
Adhesions 40 19.80 Low Low
Proliferative Vitreoretinopathy 10 18.48 Low Low
Death 10 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since there is a strong association between EBP50 and Ezrin [33,36], we also probed the immunoprecipitated proteins with anti-Ezrin antibodies, observing a strong band (Figure 2C).
EBP50 Binding (association) of in band
1) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Immunoprecipitation studies confirmed an association among CD81, Sap97, and EBP50.
EBP50 Binding (association) of
2) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
If the CD81/EBP50 complex is associated with the ingestion of shed outer rod segments, this association through EBP50 would bring the molecular machinery for retinoid processing into direct association with the shed outer rod segments.
EBP50 Binding (association) of
3) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
To directly test for the binding of CD81 to Sap97 and EBP50, we did a series of immunoprecipitation studies.
EBP50 Binding (binding) of
4) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
It is tempting to speculate that the PDZ protein EBP50 links the CD81 complex in the microvilli to CRALBP.
EBP50 Binding (links) of
5) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Due to the distinct locations of these two PDZ proteins within the RPE, CD81 must be involved in at least two different molecular complexes, one in the microvilli associated with EBP50/Ezrin and the other associated with Sap97 on the lateral and basal cell surfaces.
EBP50 Binding (associated) of in basal cell
6) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
To determine if the CD81 associated with Sap97 or EBP50, we used double-label immunohistochemistry similar to that described in Clarke and Geisert [3].
EBP50 Binding (associated) of
7) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.06 Pain Relevance 0.17
If the CD81/EBP50 complex is associated with the ingestion of shed outer rod segments, this association through EBP50 would bring the molecular machinery for retinoid processing into direct association with the shed outer rod segments.
EBP50 Binding (associated) of
8) Confidence 0.29 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
At P0 (Figure 4A-C, Figure 4M-O), there is little immunolabeling for Sap97 (Figure 4A), CD81 (Figure 4B,N), or EBP50 (Figure 4M).
EBP50 Binding (immunolabeling) of
9) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Due to the distinct locations of these two PDZ proteins within the RPE, CD81 must be involved in at least two different molecular complexes, one in the microvilli associated with EBP50/Ezrin and the other associated with Sap97 on the lateral and basal cell surfaces.
EBP50 Binding (associated) of in lateral
10) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Perhaps more importantly, we show that the plateau current of ASIC3 can be dramatically increased (10-30-fold) by association with NHERF-1, leading to a significant sustained current at pH 6.6.
NHERF-1 Binding (association) of
11) Confidence 0.07 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.26 Pain Relevance 0.42

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