INT130972

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.36
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3r1) nucleus (Slc9a3r1) cytoplasm (Slc9a3r1)
Anatomy Link Frequency
retina 1
neurons 1
Slc9a3r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 1 99.56 Very High Very High Very High
Kinase C 1 95.12 Very High Very High Very High
Mechanosensation 2 93.00 High High
dorsal root ganglion 1 91.04 High High
Pain 1 90.96 High High
Peripheral nervous system 1 89.76 High High
ASIC 1 84.52 Quite High
nociceptor 2 42.88 Quite Low
anesthesia 18 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 99.36 Very High Very High Very High
Pain 1 90.96 High High
Adhesions 24 5.00 Very Low Very Low Very Low
Injury 18 5.00 Very Low Very Low Very Low
Hypothermia 12 5.00 Very Low Very Low Very Low
Proliferative Vitreoretinopathy 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further explore the relationship between CD81 and these PDZ proteins, we examined the levels of CD81 and EBP50 in the developing retina, running a series of immunoblots on samples of retina taken at different postnatal time points (Figure 3).
Spec (examined) Gene_expression (levels) of EBP50 in retina
1) Confidence 0.63 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Sap97 and EBP50 contain all of the types of PDZ domains labeled by the CD81 C-terminal peptide.
Gene_expression (contain) of EBP50
2) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
We found, as with CD81, that the levels of EBP50 were low at P0 but high by P20.
Gene_expression (levels) of EBP50
3) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
Like CD81, EBP50 and Sap97 are expressed at low levels immediately after birth and upregulated during the first two postnatal weeks, reaching almost adult levels at postnatal day 20.
Gene_expression (expressed) of EBP50
4) Confidence 0.49 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
We next focused on the general pattern of CD81, EBP50 and Sap97, at two time points, P2 (Figure 6) and P20 (Figure 5).
Gene_expression (pattern) of EBP50
5) Confidence 0.49 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.08 Pain Relevance 0
Two candidate proteins were immediately obvious, Sap97 and EBP50, both expressed at high levels in RPE.
Gene_expression (expressed) of EBP50
6) Confidence 0.49 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0 Pain Relevance 0
We show that NHERF-1 and ASIC3 are co-expressed in dorsal root ganglion neurons.
Gene_expression (co-expressed) of NHERF-1 in neurons associated with ganglion cysts and root ganglion neuron
7) Confidence 0.14 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.28 Pain Relevance 0.37

General Comments

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