INT130998

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 5.70
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAB1) signal transduction (PRKAB1) nucleus (PRKAB1)
Anatomy Link Frequency
lips 1
skeletal muscle 1
adipocytes 1
PRKAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 20 99.64 Very High Very High Very High
agonist 41 99.38 Very High Very High Very High
abdominal pain 4 78.36 Quite High
monoamine 2 60.40 Quite High
ischemia 3 58.16 Quite High
Endocannabinoid 2 56.48 Quite High
drug abuse 57 56.08 Quite High
antagonist 74 54.48 Quite High
tolerance 12 54.20 Quite High
cocaine 28 50.00 Quite Low
Disease Link Frequency Relevance Heat
Obesity 93 99.84 Very High Very High Very High
Apoptosis 81 98.54 Very High Very High Very High
Gastrointestinal Neoplasms 2 98.02 Very High Very High Very High
Cancer 265 97.34 Very High Very High Very High
Glioma 2 97.08 Very High Very High Very High
Disorder Of Lipid Metabolism 17 96.64 Very High Very High Very High
Polyps 4 96.44 Very High Very High Very High
Metabolic Disorder 8 95.92 Very High Very High Very High
Cardiovascular Disease 19 95.76 Very High Very High Very High
Diabetes Mellitus 56 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We determined that the R225W mutation had an overall effect on AMPK activity.
Regulation (effect) of AMPK
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
In the present study, the molecular basis of selective phytochemicals with emphasis on their ability to control intracellular signaling cascades of AMP-activated kinase (AMPK) responsible for the inhibition of adipogenesis was investigated.
Regulation (control) of AMPK
2) Confidence 0.42 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.48 Pain Relevance 0.20
In the present study, the molecular basis of selective phytochemicals with emphasis on their ability to control intracellular signaling cascades of AMP-activated kinase (AMPK) responsible for the inhibition of adipogenesis was investigated.
Regulation (control) of AMP-activated kinase
3) Confidence 0.42 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.48 Pain Relevance 0.19
Although R225W carriers demonstrate twice the AMP-stimulated AMPK activity of control subjects, the similar percent increases indicate that R225W AMPK is likely activated by AMP with a similar magnitude to control AMPK.
Regulation (control) of AMPK
4) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
There were no differences in either AMPK?
Neg (no) Regulation (differences) of AMPK
5) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
3 subunit of AMPK is expressed exclusively in skeletal muscle; however, its importance in controlling overall AMPK activity is unknown.
Regulation (controlling) of AMPK in skeletal muscle
6) Confidence 0.29 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1964808 Disease Relevance 0.35 Pain Relevance 0
While the functions of the three AMPK subunits have not been fully characterized, it is becoming increasingly clear that the ?
Regulation (functions) of AMPK
7) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.05 Pain Relevance 0
Recently, the evolutionarily conserved serine/threonine kinase, AMPK, emerges as a possible target molecule of anti-obesity.
Spec (possible) Regulation (target) of AMPK associated with obesity
8) Confidence 0.25 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.49 Pain Relevance 0.22
We suggest that AMPK is a novel and critical component of both inhibition of adipocyte differentiation and apoptosis of mature adipocytes by genistein or EGCG or capsaicin further implying AMPK as a prime target of obesity control.
Regulation (target) of AMPK in adipocytes associated with qutenza, obesity and apoptosis
9) Confidence 0.22 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.72 Pain Relevance 0.34
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Regulation (regulating) of PRKAB1 associated with disorder of lipid metabolism
10) Confidence 0.15 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.03
Whether their antitumor actions depend on AMPK activation or whether these are independent of this pathway requires further study.
Spec (Whether) Regulation (depend) of AMPK
11) Confidence 0.14 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.04 Pain Relevance 0.09
The discovery of LKB1 as the tumor suppressor gene responsible for Peutz-Jegher syndrome, an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps, and an increased risk for various neoplasms including gastrointestinal cancer led to the suspicion that metformin may exhibit antitumor properties, because LKB1 is an upstream AMPK regulator [264].
Regulation (regulator) of AMPK in lips associated with syndrome, cancer, gastrointestinal neoplasms and polyps
12) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.72 Pain Relevance 0.13
Recently, it has been recognized that PPAR agonists have physiological effects by modulating the activity of AMP-activated protein kinase (AMPK), an important cellular energy sensor [5–9].
Regulation (modulating) of AMP-activated protein kinase associated with agonist
13) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.16 Pain Relevance 0.13

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