INT1310

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Context Info
Confidence 0.40
First Reported 1977
Last Reported 1999
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.61
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Prl) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 2
3rd ventricle 2
central nervous system 2
Pomc (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 13 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Neuropeptide 1 99.98 Very High Very High Very High
narcan 19 99.18 Very High Very High Very High
opiate 10 99.16 Very High Very High Very High
Endogenous opioid 3 99.16 Very High Very High Very High
antagonist 22 98.88 Very High Very High Very High
opioid receptor 4 98.12 Very High Very High Very High
Central nervous system 2 97.68 Very High Very High Very High
Dopamine 6 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Body Weight 2 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gamma-Endorphin did not affect the prolactin secretion by hemipituitary glands incubated in vitro and by cultured pituitary cells, but it reversed, in a dose-dependent way, the dopamine-induced inhibition of prolactin release.
Gamma-Endorphin Neg (not) Regulation (affect) of Localization (secretion) of prolactin in pituitary associated with dopamine
1) Confidence 0.40 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6184642 Disease Relevance 0 Pain Relevance 0.46
The in vivo stimulatory effects of beta-endorphin on prolactin secretion are reversed by the opiate antagonist naloxone.
beta-endorphin Regulation (effects) of Localization (secretion) of prolactin associated with antagonist, narcan and opiate
2) Confidence 0.31 Published 1977 Journal Endocrinology Section Abstract Doc Link 187406 Disease Relevance 0 Pain Relevance 0.50
The absence of in vitro effect of MS and beta-endorphin on prolactin and growth hormone secretion by cultured rat pituitary cells suggest that they have a central nervous system site of action.
beta-endorphin Regulation (effect) of Localization (secretion) of prolactin in central nervous system associated with central nervous system
3) Confidence 0.23 Published 1977 Journal Endocrinology Section Abstract Doc Link 187406 Disease Relevance 0 Pain Relevance 0.49
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
beta-endorphin Regulation (effect) of Localization (secretion) of prolactin in 3rd ventricle associated with enkephalin
4) Confidence 0.17 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.48
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
beta-endorphin Regulation (effect) of Localization (release) of PRL associated with narcan
5) Confidence 0.14 Published 1985 Journal Endocrinology Section Title Doc Link 2981076 Disease Relevance 0 Pain Relevance 0.49
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
beta-endorphin Regulation (effect) of Localization (release) of prolactin associated with narcan
6) Confidence 0.14 Published 1985 Journal Endocrinology Section Title Doc Link 2981076 Disease Relevance 0 Pain Relevance 0.49
Comparison of acute effects of dynorphin and beta-endorphin on prolactin release in the rat.
beta-endorphin Regulation (effects) of Localization (release) of prolactin associated with dynorphin
7) Confidence 0.08 Published 1981 Journal Endocrinology Section Title Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.64
Beta-endorphin and dynorphin participate in the stress-induced release of prolactin in the rat.
Beta-endorphin Regulation (participate) of Localization (release) of prolactin associated with stress and dynorphin
8) Confidence 0.08 Published 1987 Journal Neuroendocrinology Section Title Doc Link 2884585 Disease Relevance 0.46 Pain Relevance 0.64
Endogenous opioid peptides (EOPs), mainly the neuropeptide beta-endorphin, have a stimulatory influence on PRL secretion.
beta-endorphin Regulation (influence) of Localization (secretion) of PRL associated with neuropeptide and endogenous opioid
9) Confidence 0.07 Published 1999 Journal Endocrine Section Abstract Doc Link 10451223 Disease Relevance 0 Pain Relevance 0.46
Effects of the glucocorticoid milieu on the basal and ether stress-induced prolactin (PRL) release and on the immunostaining for hypothalamic vasoactive intestinal peptide (VIP), beta-endorphin (beta-EP), dynorphin-A (DYN-A) and methionine-enkephalin (Met-ENK), were examined in separate groups of male rats.
beta-endorphin Spec (examined) Regulation (Effects) of Localization (release) of PRL associated with stress, dynorphin and enkephalin
10) Confidence 0.04 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1974081 Disease Relevance 0.15 Pain Relevance 0.29

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