INT131001

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.77
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
neurons 1
colon 1
epithelial cells 1
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 14 97.04 Very High Very High Very High
alcohol 2 95.36 Very High Very High Very High
Morphine 1 82.88 Quite High
cINOD 1 82.40 Quite High
nMDA receptor antagonist 1 82.28 Quite High
tetrodotoxin 9 74.52 Quite High
Inflammation 11 71.20 Quite High
cytokine 5 70.16 Quite High
Spinal cord 1 69.72 Quite High
agonist 38 54.96 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 7 100.00 Very High Very High Very High
Malignant Neoplastic Disease 8 99.24 Very High Very High Very High
Colon Cancer 6 97.64 Very High Very High Very High
Prostate Cancer 99 97.44 Very High Very High Very High
Cancer 124 96.54 Very High Very High Very High
Adenocarcinoma 51 96.20 Very High Very High Very High
Metastasis 38 95.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 92.84 High High
Apoptosis 4 90.24 High High
Infection 38 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows that changes specifically affecting CaV1.3 channel contribution to intrinsic oscillatory property expression may occur in culture.
Regulation (affecting) of CaV1
1) Confidence 0.44 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16236781 Disease Relevance 0 Pain Relevance 0.15
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1

Background

Regulation (Regulation) of Caveolin-1 associated with pancreatic cancer
2) Confidence 0.26 Published 2005 Journal Mol Cancer Section Title Doc Link PMC1173138 Disease Relevance 0.95 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Regulation (target) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
3) Confidence 0.26 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.26 Pain Relevance 0
Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
Regulation (effects) of caveolin-1 in colon associated with colon cancer
4) Confidence 0.19 Published 2009 Journal Int. J. Oncol. Section Title Doc Link 19787257 Disease Relevance 0.44 Pain Relevance 0.08
The A kinase anchoring protein 150 (AKAP150) is critical for regulating CaV1.2 (L-type) voltage-gated Ca2+ channels in cardiac myocytes [54], [55] and neurons [56].
Regulation (regulating) of CaV1 in neurons
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.06 Pain Relevance 0.08
Since mutation of the caveolin-binding site had a significant effect on activation of the maxi-K channel, we next determined the role of the caveolin-binding motif in regulating localization of the maxi-K channel within lipid rafts.
Spec (determined) Regulation (role) of caveolin-binding
6) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
The effect of Tat is dependent on caveolin-1 and its modulation of Ras signaling.


Regulation (dependent) of caveolin-1
7) Confidence 0.03 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.07 Pain Relevance 0.28

General Comments

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