INT131017

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.89
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
mononuclear cells 4
cardiac myocyte 2
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 12 83.60 Quite High
Multiple sclerosis 2 79.60 Quite High
Inflammation 2 71.56 Quite High
fibrosis 1 66.88 Quite High
cytokine 6 25.00 Low Low
Endocannabinoid 2 25.00 Low Low
carbamazepine 4 20.04 Low Low
Clonidine 1 19.32 Low Low
Buprenorphine 1 14.88 Low Low
addiction 6 8.48 Low Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 13 98.96 Very High Very High Very High
Hypertrophy 1 95.16 Very High Very High Very High
Multiple Sclerosis 2 95.04 Very High Very High Very High
Apoptosis 23 94.96 High High
Cancer 92 93.28 High High
Increased Venous Pressure Under Development 4 83.88 Quite High
Death 7 82.88 Quite High
Encephalitis 2 75.00 Quite High
INFLAMMATION 2 71.56 Quite High
Contracture 1 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (inducing) of Positive_regulation (activation) of p21waf in mononuclear cells
1) Confidence 0.67 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.26 Pain Relevance 0.12
AMPK activation suppresses protein synthesis and prevents cardiac myocyte hypertrophy by regulation of the eEF2 kinase/eEF2 axis and/or TSC2-mTOR-P70S6 pathways.22-24) LKB1 has been reported to cause G1 growth arrest in cultured cells via induction of p21WAF1/CIP111) and stimulation of Brg1 ATPase.25) LKB1 kinase activity is required for p21WAF1/CIP1 induction, and overexpression of LKB1 causes p21WAF1/CIP1-induced growth arrest in cells with undetectable or low levels of endogenous LKB1.11) In contrast to kinase activity, although Brg1-associated growth arrest also requires LKB1 kinase activity, wild-type LKB1 and the kinase-deficient form LKB1-SL26 both stimulate Brg1 ATPase.25) This suggests that some regulatory functions of LKB1 may not require its kinase activity.19) As is well known, LKB1 has an autophosphorylation activity to increased its kinase activity.
Positive_regulation (required) of Positive_regulation (induction) of CIP1 in cardiac myocyte associated with hypertrophy
2) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.33 Pain Relevance 0
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Positive_regulation (inducing) of Positive_regulation (activation) of cip-1 in mononuclear cells
3) Confidence 0.24 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
G1 cell cycle arrest is, in most cases, a result of the induction of the CDKN1A gene, which encodes the cyclin-dependent kinase inhibitor WAF1 (also known as p21; Richon et al. 2000).
Positive_regulation (result) of Positive_regulation (induction) of CDKN1A gene
4) Confidence 0.16 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.30 Pain Relevance 0
VPA appears to induce an increase in the amount of p21WAF1 protein over 48 hours in AML cells, which is independent of p53 levels (whose expression is not modulated by VPA), but appears to be dependent on c-myc, whose mRNA and protein levels decrease in a dose-dependent manner during VPA treatment.
Positive_regulation (induce) of Positive_regulation (increase) of p21WAF1 associated with myeloid leukemia
5) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.72 Pain Relevance 0.07

General Comments

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