INT131018

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
chondrocyte 1
mononuclear cells 1
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 82.32 Quite High
Multiple sclerosis 1 81.20 Quite High
Chronic pancreatitis 4 79.04 Quite High
cytokine 1 25.00 Low Low
Endocannabinoid 1 25.00 Low Low
Pain 4 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 99.16 Very High Very High Very High
Multiple Sclerosis 1 96.64 Very High Very High Very High
Apoptosis 4 94.92 High High
Repression 1 93.84 High High
Pancreatic Cancer 57 89.44 High High
Sarcoma 4 88.24 High High
Osteochondroma 40 82.48 Quite High
Pancreatitis 4 79.04 Quite High
Cancer 59 78.88 Quite High
Encephalitis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, activation of FGFR3 in the proliferative zone (Fig. 5), by FGF18 [84] inhibits chondrocyte proliferation via phosphorylation of STAT-1 and subsequent upregulation of p21WAF/CIP1, which can inhibit the cell cycle [85].
Phosphorylation (phosphorylation) of p21WAF in chondrocyte
1) Confidence 0.61 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.38 Pain Relevance 0
Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB.
Phosphorylation (phosphorylation) of cip-1 in mononuclear cells
2) Confidence 0.30 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.27 Pain Relevance 0.12
WAF1, that is activated by wild type p53, but not by mutated p53, inhibits the activation of cyclin-CDK complex and the phosphorylation and inactivation of Retinoblastoma proteins thereby stopping the progression of cell cycle in phase G1.
Phosphorylation (phosphorylation) of WAF1 associated with retinoblastoma
3) Confidence 0.22 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.41 Pain Relevance 0.28

General Comments

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