INT131072

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cc2d1b, Prkcg) cytosol (Prkcg) plasma membrane (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
hippocampus 1
Cc2d1b (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
Nicotine 2 95.12 Very High Very High Very High
Neurotransmitter 1 93.86 High High
Hippocampus 2 92.98 High High
gABA 7 92.72 High High
tetrodotoxin 1 88.56 High High
Pyramidal cell 3 75.00 Quite High
agonist 2 44.32 Quite Low
GABAergic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nicotinic acetylcholine (ACh) receptors, such as alpha7, alpha3beta4 and alpha4beta2 receptors in the hippocampus, are suggested to modulate neurotransmitter release. 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (100 nM), a linoleic acid derivative, potentiated responses of alpha7, alpha3beta4 and alpha4beta2 ACh receptors expressed in Xenopus oocytes that are blocked by 3-(1-[dimethylaminopropyl] indol-3-yl)-4-[indol-3-yl] maleimide (GF109203X), a selective inhibitor of protein kinase C (PKC), except for alpha3beta4 ACh receptors.
GF109203X Negative_regulation (inhibitor) of PKC in hippocampus associated with kinase c, neurotransmitter and hippocampus
1) Confidence 0.01 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16248884 Disease Relevance 0 Pain Relevance 0.58

General Comments

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