INT131112

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.10
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 30 99.52 Very High Very High Very High
fibrosis 14 95.88 Very High Very High Very High
anesthesia 9 95.36 Very High Very High Very High
Hippocampus 2 80.96 Quite High
ketamine 12 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 78 97.80 Very High Very High Very High
Apoptosis 86 97.68 Very High Very High Very High
Death 24 97.24 Very High Very High Very High
Cardiovascular Disorder Under Development 2 95.88 Very High Very High Very High
Drug Induced Neurotoxicity 4 94.44 High High
Coronary Heart Disease 10 94.04 High High
Adhesions 5 93.40 High High
Diabetes Mellitus 57 90.44 High High
Toxicity 2 86.60 High High
Alzheimer's Dementia 2 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Fig. 2F)

Immunostaining of the active form of Caspase-3 and colocalized with AVP

Phosphorylation (form) of Caspase-3
1) Confidence 0.63 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.09 Pain Relevance 0
The effects of lidocaine and bupivacaine on protein expression of cleaved caspase 3 and tyrosine phosphorylation in the rat hippocampal slice.
Phosphorylation (phosphorylation) of caspase 3 associated with lidocaine
2) Confidence 0.45 Published 2007 Journal Anesth. Analg. Section Title Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.72
Here, we compared the effects of lidocaine and bupivacaine on FAK phosphorylation and cleaved caspase 3 expression in rat hippocampal slices.
Phosphorylation (phosphorylation) of caspase 3 associated with lidocaine
3) Confidence 0.45 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.19 Pain Relevance 0.71
Caspase 3 expression and FAK phosphorylation were examined by immunoblotting.
Phosphorylation (phosphorylation) of Caspase 3
4) Confidence 0.35 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.86
Western blotting was used to study Caspase-3, Bax, Sirt1, acetylation of p53 and phosphorylation of p38, Akt and FOXO3a.
Phosphorylation (phosphorylation) of Caspase-3
5) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.50 Pain Relevance 0.09
FAK phosphorylation and caspase-3 activation were examined by immunoblotting.
Phosphorylation (phosphorylation) of caspase-3
6) Confidence 0.26 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
peptide-triggered caspase-3-like activity and the phosphorylation of PKR [26].
Phosphorylation (phosphorylation) of caspase-3
7) Confidence 0.15 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.98 Pain Relevance 0.08

General Comments

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