INT131113

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.17
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) cytoskeleton (Ptk2)
nucleus (Ptk2) extracellular matrix organization (Ptk2) microtubule organizing center (Ptk2)
Anatomy Link Frequency
neuronal 1
Ptk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 10 98.06 Very High Very High Very High
Dynorphin 9 98.00 Very High Very High Very High
anesthesia 1 76.56 Quite High
dorsal root ganglion 42 5.00 Very Low Very Low Very Low
opioid receptor 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 4 87.80 High High
Adhesions 6 83.96 Quite High
Ganglion Cysts 42 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Diuresis 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Slices were treated with increasing concentrations of lidocaine (4.3 nM to 4.3 mM) or bupivacaine (3.4 nM to 3.4 mM) in the presence or absence of the specific inhibitor of the FAK tyrosine kinase PP2 (10 microM).
Negative_regulation (inhibitor) of FAK tyrosine kinase associated with lidocaine
1) Confidence 0.58 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.80
In OGD conditions, a preconditioning application of dexmedetomidine (0.2 microm, 20-min application, 3 h before anoxia) significantly reduced neuronal death and cleaved caspase-3 expression and significantly attenuated the decrease in phosphorylated FAK content.
Negative_regulation (decrease) of FAK in neuronal
2) Confidence 0.42 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
PF 573228 and FAK inhibitor 14 were obtained from Tocris Bioscience.
Negative_regulation (inhibitor) of FAK
3) Confidence 0.32 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0.05
Importantly, blocking FAK function failed to inhibit EGF-stimulated Grb7 and KOR mRNA export (Fig. 5 A, right), suggesting the specificity of FAK in phosphorylating cytoplasmic Grb7.
Negative_regulation (blocking) of FAK
4) Confidence 0.31 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 5 A, EGF induced an increase in the phosphorylation of cytoplasmic Grb7, which was blocked by FAK inhibitor PF 573228 (Slack-Davis et al., 2007) and FAK inhibitor 14 (Golubovskaya et al., 2008) as well as by silencing FAK.
Negative_regulation (inhibitor) of FAK
5) Confidence 0.31 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

General Comments

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