INT131123

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 3.74
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gba) carbohydrate metabolic process (Gba) lipid metabolic process (Gba)
lysosome (Gba)
Anatomy Link Frequency
urine 3
liver 2
bile 2
blood 1
visceral 1
Gba (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 34 100.00 Very High Very High Very High
Bile 6 99.84 Very High Very High Very High
isoflurane 32 84.76 Quite High
Potency 8 82.40 Quite High
Pain 20 78.00 Quite High
Buprenorphine 21 50.00 Quite Low
imagery 14 47.52 Quite Low
Inflammatory response 16 29.28 Quite Low
Antihistamine 16 23.44 Low Low
corticosteroid 16 20.80 Low Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 32 99.68 Very High Very High Very High
Lysosomal Storage Diseases 2 99.20 Very High Very High Very High
Gauchers Disease 260 98.30 Very High Very High Very High
Body Weight 32 86.32 High High
Hepatotoxicity 6 85.92 High High
Stroke 16 85.04 High High
Anaemia 18 84.80 Quite High
Thrombocytopenia 18 84.16 Quite High
Stupor 16 83.44 Quite High
Pain 20 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, GCase has been produced by gene activation in a human fibrosarcoma cell line (velaglucerase alfa, Vela).
Gene_expression (produced) of GCase associated with fibrosarcoma
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.10 Pain Relevance 0
GCase activities are expressed as nmoles/h/mg of tissue protein or nmoles/h/ml of serum.
Gene_expression (expressed) of GCase
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.13 Pain Relevance 0
The present results are consistent with those from previous studies in which GCase was expressed in the baculovirus system [28], [29]; the R495H had no influence on the in vitro kinetic properties or stability of the enzyme relative to the R495 GCase [28], [29].
Gene_expression (expressed) of GCase
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.12 Pain Relevance 0
Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD) and therapeutic efficacy of GCase were found with two human GCases, recombinant GCase (CHO cell, imiglucerase, Imig) and gene-activated GCase (human fibrosarcoma cells, velaglucerase alfa, Vela), in a Gaucher mouse, D409V/null.
Gene_expression (found) of GCase associated with fibrosarcoma
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873993 Disease Relevance 0.26 Pain Relevance 0
The GCase protein disappearance was concordant with the activity (t½?
Gene_expression (disappearance) of GCase protein
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
Tissue and serum collection and GCase assay
Gene_expression (assay) of GCase
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.08 Pain Relevance 0.04
In visceral tissues, the GCase activities were ?
Gene_expression (activities) of GCase in visceral
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
-mannosidase I and prohibits the cleavage of extended mannosyl structures present on the nascent GCase prior to its modification and remodeling in the Golgi [41], [42].
Gene_expression (prohibits) of GCase in cleavage
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
CRIM-SA was based on the amount (ng) of intact GCase (Mr?
Gene_expression (based) of GCase
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.14 Pain Relevance 0
Concurrent GCase CRIM determinations in serum showed a similar disappearance profile, with t½?
Spec (determinations) Gene_expression (determinations) of GCase CRIM
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.08 Pain Relevance 0
Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD) and therapeutic efficacy of GCase were found with two human GCases, recombinant GCase (CHO cell, imiglucerase, Imig) and gene-activated GCase (human fibrosarcoma cells, velaglucerase alfa, Vela), in a Gaucher mouse, D409V/null.
Gene_expression (found) of GCase associated with fibrosarcoma
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873993 Disease Relevance 0.26 Pain Relevance 0
Protease susceptibilities of the two GCases were evaluated by cathepsin D (1–2 µM) digestion in 25 mM sodium acetate, pH 4.8, 50 mM NaCl, 1.25 mM EDTA, 1.25 mM DTT using 200 ng of Vela or Imig at 37°C for 4 h [29].
Gene_expression (susceptibilities) of GCase
12) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD) and therapeutic efficacy of GCase were found with two human GCases, recombinant GCase (CHO cell, imiglucerase, Imig) and gene-activated GCase (human fibrosarcoma cells, velaglucerase alfa, Vela), in a Gaucher mouse, D409V/null.
Gene_expression (found) of GCase associated with fibrosarcoma
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873993 Disease Relevance 0.26 Pain Relevance 0
Serum GCase activities
Gene_expression (activities) of Serum GCase
14) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.09 Pain Relevance 0
In the mice receiving the 60 U/kg/wk dose, serum anti-GCase IgG levels increased ?
Gene_expression (levels) of anti-GCase
15) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.07 Pain Relevance 0
ELISA was used to determine the mouse anti-GCase IgG levels.
Spec (determine) Gene_expression (levels) of anti-GCase
16) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Gene_expression (production) of glucocerebrosidase in spleen associated with lysosomal storage diseases and gauchers disease
17) Confidence 0.11 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.85 Pain Relevance 0.08
In addition, APAP-GLUC excretion in bile of Mrp3-/- mice was tenfold higher than in Mrp3+/+ mice.
Gene_expression (excretion) of APAP-GLUC in bile associated with bile and paracetamol
18) Confidence 0.09 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.24 Pain Relevance 1.43
In addition, APAP-GLUC excretion in bile of Mrp3-/- mice was tenfold higher than in Mrp3+/+ mice.
Gene_expression (excretion) of APAP-GLUC in bile associated with bile and paracetamol
19) Confidence 0.09 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.24 Pain Relevance 1.43
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Gene_expression (production) of glucocerebrosidase in liver associated with lysosomal storage diseases and gauchers disease
20) Confidence 0.04 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

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