INT131124

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.48
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc3) ATPase activity (Abcc3) transmembrane transport (Abcc3)
Anatomy Link Frequency
enterocytes 1
hepatocytes 1
Abcc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 55 100.00 Very High Very High Very High
Bile 9 92.48 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 9 95.32 Very High Very High Very High
Targeted Disruption 3 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, basolateral excretion of APAP-GLUC in mice is nearly completely dependent on the function of Mrp3.
Localization (excretion) of Mrp3 associated with paracetamol
1) Confidence 0.75 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.22 Pain Relevance 1.37
In the present study, the involvement in this process of Mrp3 and Mrp4, two basolateral efflux transporters, was evaluated by analyzing the hepatic basolateral excretion of the glucuronide and sulfate metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3(-/-) and Abcc4(-/-) mice using a cassette dosing approach.
Spec (analyzing) Localization (excretion) of Abcc3 associated with paracetamol
2) Confidence 0.74 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16988054 Disease Relevance 0 Pain Relevance 0.33
MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes.
Localization (localized) of MRP3 in enterocytes
3) Confidence 0.70 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.13 Pain Relevance 0.51
MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes.
Localization (localized) of MRP3 in hepatocytes
4) Confidence 0.24 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.13 Pain Relevance 0.51

General Comments

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