INT131132

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Context Info
Confidence 0.86
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.02
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
synapses 1
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 60 81.76 Quite High
Inflammation 51 75.32 Quite High
cINOD 4 68.56 Quite High
Glutamate receptor 10 63.48 Quite High
Inflammatory response 9 54.12 Quite High
tetrodotoxin 20 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 12 89.80 High High
Disease 12 78.12 Quite High
Colon Cancer 9 77.28 Quite High
INFLAMMATION 59 75.32 Quite High
Cancer 152 73.64 Quite High
Neurodegenerative Disease 1 73.32 Quite High
Angelman Syndrome 5 65.68 Quite High
Syndrome 10 64.68 Quite High
Intellectual Impairment 5 64.32 Quite High
Targeted Disruption 21 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These fluorescent UPS reporters contain specific degradation signals that target them with high efficiency and accuracy for proteasomal degradation.
Protein_catabolism (degradation) of UPS
1) Confidence 0.86 Published 2005 Journal Essays Biochem. Section Abstract Doc Link 16250901 Disease Relevance 0.30 Pain Relevance 0.11
UPS-dependent proteolysis, which may affect greatly the ligand-independent
Protein_catabolism (proteolysis) of UPS
2) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0 Pain Relevance 0
UPS-mediated degradation.
Protein_catabolism (degradation) of UPS
3) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.25 Pain Relevance 0
proteins that undergo ubiquitination and proteosomal degradation and the UPS is
Protein_catabolism (degradation) of UPS
4) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.28 Pain Relevance 0.10
Proteins are generally targeted for degradation by the UPS by the covalent addition of polyubiquitin chains.
Protein_catabolism (degradation) of UPS
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0.03
WD repeats can specifically recognize phosphorylated substrates for UPS-mediated degradation [35]–[37].
Protein_catabolism (degradation) of UPS
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
In addition to being itself a target of UPS degradation [3], Shank1A is localized to synapses, and its accumulation requires other scaffold proteins in the PSD, including GKAP, Homer, and PSD-95 [16], [17], [25].
Protein_catabolism (degradation) of UPS in synapses
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.19 Pain Relevance 0
E3 ubiquitin ligases, hundreds of which exist in mammalian genomes, appear to recognize specific proteins and thus determine the specificity of protein substrates targeted for UPS-mediated degradation [9].
Protein_catabolism (degradation) of UPS
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
Overall, our data indicate that GKAP is more likely than Shank1A to be a conventional substrate of TRIM3-mediated UPS degradation.
Protein_catabolism (degradation) of UPS
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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