INT131136

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.44
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
dorsal root ganglia 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 52 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Pain 43 94.48 High High
ischemia 13 88.16 High High
Root ganglion neuron 1 76.40 Quite High
Inflammatory stimuli 1 75.00 Quite High
agonist 6 72.64 Quite High
Inflammation 57 50.00 Quite Low
IPN 23 25.00 Low Low
Nerve growth factor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.08 Very High Very High Very High
Aids-related Complex 24 95.56 Very High Very High Very High
Pain 39 94.48 High High
Ganglion Cysts 4 76.00 Quite High
INFLAMMATION 61 75.00 Quite High
Nociception 2 42.48 Quite Low
Myalgia 4 35.52 Quite Low
Hypersensitivity 3 28.72 Quite Low
Inflammatory Pain 23 25.00 Low Low
Acidosis 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Existing ASIC knock-out mouse experiments are complicated by the heteromultimerization of ASIC subunits.
ASIC Binding (heteromultimerization) of associated with targeted disruption and asic
1) Confidence 0.36 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16251436 Disease Relevance 0.63 Pain Relevance 0.45
ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.
ASIC2a Binding (heteromultimerize) of in dorsal root ganglia associated with qutenza
2) Confidence 0.35 Published 2009 Journal Circ. Res. Section Title Doc Link 19590043 Disease Relevance 0 Pain Relevance 0.19
On the other hand, heteromeric combinations of ASIC3 plus ASIC1a, ASIC2a, or ASIC2b were insensitive to these ligands (Figure 7B, D).
ASIC2b Binding (combinations) of
3) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.20
On the other hand, heteromeric combinations of ASIC3 plus ASIC1a, ASIC2a, or ASIC2b were insensitive to these ligands (Figure 7B, D).
ASIC2a Binding (combinations) of
4) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.20
On the other hand, heteromeric combinations of ASIC3 plus ASIC1a, ASIC2a, or ASIC2b were insensitive to these ligands (Figure 7B, D).
ASIC1a Binding (combinations) of
5) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.20

General Comments

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