INT131139

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1)
Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)
Anatomy Link Frequency
hepatocytes 1
ACO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 84.72 Quite High
Analgesic 1 53.52 Quite High
Inflammation 48 49.52 Quite Low
Pain 2 9.92 Low Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 29 97.20 Very High Very High Very High
Poisoning 6 96.56 Very High Very High Very High
Disease 45 89.72 High High
Stress 111 88.08 High High
Injury 46 81.84 Quite High
Toxicity 4 75.32 Quite High
Fibrosis 37 63.12 Quite High
Ataxia 24 60.80 Quite High
Alcoholic Liver Diseases 19 59.48 Quite High
Nash(non-alcoholic Steatohepatitis) 12 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Firstly, competitive inhibition of FA interaction with CoA and of FC interaction with aconitase.
aconitase Binding (interaction) of
1) Confidence 0.27 Published 2006 Journal J Appl Toxicol Section Abstract Doc Link 16252258 Disease Relevance 0.55 Pain Relevance 0.10
The cytosolic iron sensors IRP1, which senses iron levels through an iron?
IRP1 Binding (senses) of
2) Confidence 0.15 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.34 Pain Relevance 0
Another concept should be recalled: intracellular levels of iron are usually carefully controlled (as in hepatocytes or macrophages) by means of iron binding to cytoplasmic Iron regulatory proteins (IRP-1 and IRP-2) and the expression of genes involved in iron homeostasis through the binding of IRPs to Iron responsive element (IRE) sequences, including those for transferrin receptor (TfR) and ferritin (Ft).
IRP-1 Binding (binding) of in hepatocytes
3) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.92 Pain Relevance 0

General Comments

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