INT131140

Context Info Confidence 0.37 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.09

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1) Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)

Anatomy Link Frequency outflow 2 ACO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 1 86.72 Glutamate 1 25.00

Disease Link Frequency Relevance Heat Poisoning 6 99.62 Toxicity 1 88.16 Death 1 82.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antidotal therapy for FA intoxication has been aimed at preventing fluorocitrate synthesis and aconitase blockade in mitochondria, and at providing citrate outflow from this organelle.

Negative_regulation (preventing) of Negative_regulation (blockade) of aconitase in outflow associated with poisoning

1) Confidence 0.37 Published 2006 Journal J Appl Toxicol Section Abstract Doc Link 16252258 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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