INT131156

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.44
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) DNA binding (RUNX1)
signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
RUNX1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 10 99.88 Very High Very High Very High
Adalimumab 5 97.88 Very High Very High Very High
Arthritis 21 95.92 Very High Very High Very High
Infliximab 8 95.36 Very High Very High Very High
cytokine 2 93.92 High High
Inflammation 16 93.56 High High
rheumatoid arthritis 30 87.96 High High
cINOD 2 86.24 High High
spinal inflammation 9 84.72 Quite High
antagonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Disease 21 98.08 Very High Very High Very High
Cancer 6 96.72 Very High Very High Very High
Seronegative Spondarthritis 14 95.92 Very High Very High Very High
Necrosis 4 94.60 High High
INFLAMMATION 11 93.56 High High
Arthropathy 2 88.20 High High
Rheumatoid Arthritis 30 87.96 High High
Low Back Pain 10 84.72 Quite High
Skin Manifestations 1 81.24 Quite High
Infection 8 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etanercept is a fully human, soluble, dimeric fusion protein that has the ability to bind to two molecules of TNF, thereby rendering them biologically inactive.
fusion protein Binding (bind) of TNF associated with etanercept
1) Confidence 0.03 Published 2005 Journal Expert Opin Biol Ther Section Abstract Doc Link 16255653 Disease Relevance 1.55 Pain Relevance 0.66
Etanercept is a fusion protein that binds TNF and has also been shown to neutralize lymphotoxin alpha which is associated with tumour growth control [5].
fusion protein Binding (binds) of TNF associated with cancer and etanercept
2) Confidence 0.01 Published 2009 Journal The Open Rheumatology Journal Section Body Doc Link PMC2714577 Disease Relevance 1.89 Pain Relevance 0.76

General Comments

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