INT131165

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.18
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Anatomy Link Frequency
neuron 4
plasma 2
nerve 2
spinal cord 2
parathyroid 2
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
antidepressant 39 99.90 Very High Very High Very High
Spinal cord 1 99.88 Very High Very High Very High
Hippocampus 37 99.00 Very High Very High Very High
Inflammation 90 98.74 Very High Very High Very High
Thermal hyperalgesia 2 98.64 Very High Very High Very High
gABA 2 98.40 Very High Very High Very High
allodynia 3 97.64 Very High Very High Very High
Neuropathic pain 4 96.92 Very High Very High Very High
midbrain 28 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 217 100.00 Very High Very High Very High
Targeted Disruption 36 99.88 Very High Very High Very High
Spinal Cord Injury 1 99.88 Very High Very High Very High
INFLAMMATION 112 98.74 Very High Very High Very High
Hyperalgesia 3 98.64 Very High Very High Very High
Stress 67 98.18 Very High Very High Very High
Acromegaly 4 97.92 Very High Very High Very High
Neuropathic Pain 7 97.64 Very High Very High Very High
Cancer 17 95.92 Very High Very High Very High
Injury 20 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the injured spinal cord, the expression of glucocorticoid receptor mRNA was increased, whereas it was decreased in N-type Ca(2+)-channel-deficient mice, in which neuropathic pain is eliminated.
Positive_regulation (increased) of Gene_expression (expression) of glucocorticoid receptor mRNA in spinal cord associated with spinal cord injury, neuropathic pain and spinal cord
1) Confidence 0.70 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256102 Disease Relevance 0.91 Pain Relevance 1.05
At a molecular level, these effects are most likely mediated via an increase in glucocorticoid receptor gene expression [11], [20], [21] and/or an increase in GABA-A and central benzodiazepine receptor levels [22].
Positive_regulation (increase) of Gene_expression (expression) of glucocorticoid receptor associated with gaba
2) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.54 Pain Relevance 0.05
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Positive_regulation (increased) of Gene_expression (expressions) of glucocorticoid receptor in parathyroid
3) Confidence 0.13 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Conversely, blocking the action of endogenous anti-inflammatory molecules, such as glucocorticoid hormones in transgenic mice expressing a glucocorticoid receptor (GR) antisense RNA, sharply increases microglial activation in response to MPTP, resulting in increased DAergic neuron vulnerability [8,10,11].
Positive_regulation (increased) of Gene_expression (expressing) of glucocorticoid receptor in neuron associated with parkinson's disease, targeted disruption and inflammation
4) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.56 Pain Relevance 0.64
Conversely, blocking the action of endogenous anti-inflammatory molecules, such as glucocorticoid hormones in transgenic mice expressing a glucocorticoid receptor (GR) antisense RNA, sharply increases microglial activation in response to MPTP, resulting in increased DAergic neuron vulnerability [8,10,11].
Positive_regulation (increases) of Gene_expression (expressing) of glucocorticoid receptor in neuron associated with parkinson's disease, targeted disruption and inflammation
5) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.53 Pain Relevance 0.62
A high level of 5-HT in the hippocampus was shown to increase nerve growth factor1-A level and induce glucocorticoid receptor gene expression during development, which alters animals' adaptation to stress in adulthood[40].
Positive_regulation (l and ) of Gene_expression ( gene expr) of glucocorticoid receptor in nerve associated with stress and hippocampus
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.16 Pain Relevance 0.15
Moreover, this stress exposure paradigm caused a rise in basal plasma corticosterone levels, paralleled with an increased expression of the glucocorticoid receptor (GR) and corticotropin-releasing factor (CRF) receptor 1 [78].
Positive_regulation (increased) of Gene_expression (expression) of glucocorticoid receptor in plasma associated with stress
7) Confidence 0.09 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 1.60 Pain Relevance 0.23
Because antidepressants can increase glucocorticoid receptor (GR) expression and potentially normalize the HPA axis, this has been proposed as one mechanism of action (Barden et al 1995; Holsboer 2000; Herr et al 2003).
Positive_regulation (increase) of Gene_expression (expression) of glucocorticoid receptor associated with antidepressant
8) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.33 Pain Relevance 0.52
However, the efficacy of these treatments in patients with CD still needs to be tested in clinical trials.85

Glucocorticoid receptor antagonists

Positive_regulation (tested) of Gene_expression (antagonists) of Glucocorticoid receptor associated with antagonist
9) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.50 Pain Relevance 0.18

General Comments

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