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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.01

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mitochondrion (Abat) signal transduction (Chrna7) plasma membrane (Chrna7)
cytoplasm (Chrna7)
Chrna7 (Rattus norvegicus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 11 100.00 Very High Very High Very High
Glutamate 6 100.00 Very High Very High Very High
tetrodotoxin 5 97.72 Very High Very High Very High
Nicotine 4 91.28 High High
Hippocampus 2 75.00 Quite High
Pyramidal cell 2 56.24 Quite High
Potency 1 25.00 Low Low


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the assay of glutamate and gamma-aminobutyric acid (GABA) with a high-performance liquid chromatography, spontaneous release of glutamate and GABA from rat hippocampal slices was significantly enhanced by mecamylamine, an inhibitor of non-alpha7 ACh receptors, or alpha-bungarotoxin, an inhibitor of alpha7 ACh receptors in the absence of tetrodotoxin (TTX), but not in the presence of TTX.
alpha-bungarotoxin Positive_regulation (enhanced) of Localization (release) of GABA associated with tetrodotoxin, gaba and glutamate
1) Confidence 0.10 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16256940 Disease Relevance 0 Pain Relevance 1.01

General Comments

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