INT131176

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 3.29
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
brain 9
microglia 3
hippocampus 1
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 31 99.84 Very High Very High Very High
Hippocampus 41 99.12 Very High Very High Very High
agonist 65 98.40 Very High Very High Very High
opioid receptor 4 98.30 Very High Very High Very High
nMDA receptor 120 97.90 Very High Very High Very High
Opioid 5 97.74 Very High Very High Very High
Inflammation 54 96.04 Very High Very High Very High
Glutamate 102 90.48 High High
Glutamate receptor 30 86.88 High High
Neurotransmitter 6 79.88 Quite High
Disease Link Frequency Relevance Heat
Disease 180 99.84 Very High Very High Very High
Alzheimer's Dementia 36 98.40 Very High Very High Very High
Drug Induced Neurotoxicity 48 96.96 Very High Very High Very High
INFLAMMATION 54 96.04 Very High Very High Very High
Toxicity 12 78.44 Quite High
Neurodegenerative Disease 12 62.88 Quite High
Heart Disease 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Amyloid Plaque 6 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of morphine for 30 days produced a significant augmentation of both the mRNA and protein expressions of serine racemase in all the brain regions, whereas no significant change in the protein expression of DAO was observed in all the brain regions.
Gene_expression (expressions) of racemase in brain associated with morphine
1) Confidence 0.64 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.65
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor-related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine augments the gene expression of serine racemase and DAO in rat brain.
Gene_expression (expression) of racemase in brain associated with agonist and morphine
2) Confidence 0.64 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.51
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.
Gene_expression (expressions) of racemase in brain associated with morphine
3) Confidence 0.64 Published 2008 Journal J. Pharmacol. Sci. Section Title Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.62
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
Gene_expression (expression) of racemase in brain associated with morphine
4) Confidence 0.62 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.41
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats.
Gene_expression (expression) of racemase in brain associated with nmda receptor, opioid receptor and morphine
5) Confidence 0.62 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.40
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor-related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine augments the gene expression of serine racemase and DAO in rat brain.
Gene_expression (synthesized) of racemase in brain associated with agonist and morphine
6) Confidence 0.56 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.47
To further elucidate the mechanism underlying the activation of NMDA receptors following chronic opioid administration, we have evaluated the effects of the chronic administration of morphine on the mRNA and protein expressions of serine racemase and DAO and on the contents of D-serine in several areas of the rat brain.
Gene_expression (expressions) of racemase in brain associated with nmda receptor, opioid and morphine
7) Confidence 0.50 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.63
and other proinflammatory stimuli, the levels of expression of serine racemase in AD brain tissue were examined.
Gene_expression (expression) of serine racemase in brain associated with disease
8) Confidence 0.24 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.84 Pain Relevance 0.05
Regulation of expression of serine racemase has not been characterized, but under normal conditions the enzyme is localized to the D-serine-containing protoplasmic astrocytes in areas of the brain rich in NMDA receptors [11].
Gene_expression (expression) of serine racemase in brain associated with nmda receptor
9) Confidence 0.24 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.40 Pain Relevance 0.54
RT-PCR of mRNA isolated from hippocampus of AD indicated a significant elevation of serine racemase expression compared to age-matched controls (AMC) (Fig. 7).
Gene_expression (expression) of serine racemase in hippocampus associated with hippocampus and disease
10) Confidence 0.21 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.81 Pain Relevance 0.05
The studies presented here document the capacity of activated microglia to express serine racemase and release D-serine, thereby implicating D-serine as a contributor to the neurotoxicity exhibited by inflammatory situations in the CNS.
Gene_expression (express) of serine racemase in microglia associated with drug induced neurotoxicity and inflammation
11) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.81 Pain Relevance 0.23
Serine racemase expression was detected in cultures of primary rat microglia and appeared to increase after activation with A?
Gene_expression (expression) of Serine racemase in microglia
12) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.06 Pain Relevance 0
Induction of serine racemase expression and D-serine release from microglia by amyloid ?
Gene_expression (expression) of serine racemase in microglia associated with alzheimer's dementia
13) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Title Doc Link PMC483052 Disease Relevance 0.38 Pain Relevance 0.25

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