INT131177

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.40
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
brain 8
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
opioid receptor 2 99.30 Very High Very High Very High
Opioid 2 99.22 Very High Very High Very High
nMDA receptor 23 98.90 Very High Very High Very High
agonist 12 97.08 Very High Very High Very High
Neurotransmitter 1 80.44 Quite High
Potency 1 76.76 Quite High
Glutamate 17 74.08 Quite High
sodium channel 1 67.92 Quite High
Inflammation 9 65.84 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 80.64 Quite High
INFLAMMATION 9 65.84 Quite High
Neurodegenerative Disease 2 63.44 Quite High
Disease 30 59.44 Quite High
Drug Induced Neurotoxicity 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Amyloid Plaque 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.
Regulation (regulating) of Gene_expression (expressions) of racemase in brain associated with morphine
1) Confidence 0.51 Published 2008 Journal J. Pharmacol. Sci. Section Title Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.62
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of racemase in brain associated with nmda receptor, opioid receptor and morphine
2) Confidence 0.36 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.40
To further elucidate the mechanism underlying the activation of NMDA receptors following chronic opioid administration, we have evaluated the effects of the chronic administration of morphine on the mRNA and protein expressions of serine racemase and DAO and on the contents of D-serine in several areas of the rat brain.
Regulation (effects) of Gene_expression (expressions) of racemase in brain associated with nmda receptor, opioid and morphine
3) Confidence 0.22 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.63
Regulation of expression of serine racemase has not been characterized, but under normal conditions the enzyme is localized to the D-serine-containing protoplasmic astrocytes in areas of the brain rich in NMDA receptors [11].
Regulation (Regulation) of Gene_expression (expression) of serine racemase in brain associated with nmda receptor
4) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.40 Pain Relevance 0.57

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