INT131178

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 4.78
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
brain 3
hippocampus 2
neuronal 1
astrocytes 1
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 165 99.84 Very High Very High Very High
Hippocampus 54 99.52 Very High Very High Very High
Glutamate 155 99.48 Very High Very High Very High
Morphine 5 98.88 Very High Very High Very High
agonist 91 98.00 Very High Very High Very High
antagonist 54 94.84 High High
Opioid 6 93.96 High High
tolerance 5 91.60 High High
addiction 3 91.04 High High
opioid receptor 2 90.16 High High
Disease Link Frequency Relevance Heat
Disease 270 99.84 Very High Very High Very High
Adenocarcinoma 4 97.44 Very High Very High Very High
Necrosis 1 95.24 Very High Very High Very High
Disease Progression 9 93.56 High High
INFLAMMATION 81 82.20 Quite High
Drug Induced Neurotoxicity 72 81.16 Quite High
Injury 9 78.32 Quite High
Cv Unclassified Under Development 9 77.92 Quite High
Metastasis 1 77.84 Quite High
Alzheimer's Dementia 54 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas.
Positive_regulation (elevation) of racemase in brain associated with morphine
1) Confidence 0.56 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.40
Our semi-quantitative analysis showed that the mRNA for serine racemase was increased in AD brain nearly three-fold relative to age-matched controls.
Positive_regulation (increased) of serine racemase in brain associated with disease
2) Confidence 0.21 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 1.28 Pain Relevance 0.14
To address the possibility of a transcriptional induction of serine racemase, a 1.5 kb sequence 5' to the luciferase coding region was cloned from human genomic DNA.
Positive_regulation (induction) of serine racemase
3) Confidence 0.21 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0 Pain Relevance 0.03
Recently, data were published consistent with the possibility that serine racemase is activated by direct binding of calcium [20]; notably, AMPA/kainate receptor activation elevates intracellular calcium levels in astrocytes [27].
Positive_regulation (activated) of serine racemase in astrocytes
4) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0 Pain Relevance 0.44
Promoter-reporter and mRNA analyses suggest that serine racemase is transcriptionally induced by A?.
Positive_regulation (induced) of serine racemase
5) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Abstract Doc Link PMC483052 Disease Relevance 0.17 Pain Relevance 0.24
Finally, a potential role for D-serine in Alzheimer's disease was further implicated by the observation that serine racemase mRNA is elevated in Alzheimer's brain tissue.
Positive_regulation (elevated) of serine racemase in brain associated with disease
6) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.47 Pain Relevance 0.35
After one day of treatment, luciferase levels indicated an induction of the presumptive serine racemase promoter by both stimuli (Fig. 4).
Positive_regulation (induction) of serine racemase
7) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0 Pain Relevance 0.13
Finally, the levels of serine racemase mRNA were elevated in Alzheimer's disease hippocampus, relative to age-matched controls.


Positive_regulation (elevated) of serine racemase in hippocampus associated with hippocampus and disease
8) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Abstract Doc Link PMC483052 Disease Relevance 0.17 Pain Relevance 0.23
treatment elevated the steady-state levels of serine racemase mRNA and protein, suggesting that increased synthesis may be involved in the release of D-serine observed under these conditions.
Positive_regulation (elevated) of serine racemase
9) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.56 Pain Relevance 0.32
Our initial analysis here indicates that there is an elevated steady-state level of serine racemase mRNA in AD hippocampus versus age-matched controls.
Positive_regulation (elevated) of serine racemase in hippocampus associated with hippocampus and disease
10) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 1.24 Pain Relevance 0.25
This review focuses on the plasticity in neuronal circuits achieved through an enhancement of synaptic activities between glutamate and NMDA receptor due to up-regulation of receptor and racemase to produce D-serine, an allosteric NMDA receptor agonist, and down-regulation of glutamate transporter, all which contribute to the counterbalance of opioid actions or anti-opioid mechanisms underlying opioid tolerance.
Positive_regulation (up-regulation) of racemase in neuronal associated with glutamate, nmda receptor, tolerance, agonist and opioid
11) Confidence 0.02 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19482614 Disease Relevance 0 Pain Relevance 1.29
LCNEC was strongly positive for CD56, CD57, chromogranin A, synaptophysin, and P504S/alpha methylacyl CoA racemase.
Positive_regulation (positive) of racemase
12) Confidence 0.00 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16723845 Disease Relevance 0.89 Pain Relevance 0.08

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