INT131179

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.87
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
brain 6
microglia 2
hippocampus 2
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 99.98 Very High Very High Very High
Hippocampus 14 99.38 Very High Very High Very High
agonist 22 96.02 Very High Very High Very High
nMDA receptor 41 95.76 Very High Very High Very High
opioid receptor 2 94.40 High High
Opioid 2 90.40 High High
Inflammation 18 45.68 Quite Low
Glutamate 34 42.32 Quite Low
antagonist 12 23.28 Low Low
imagery 8 21.68 Low Low
Disease Link Frequency Relevance Heat
Disease 60 99.50 Very High Very High Very High
Drug Induced Neurotoxicity 16 85.00 Quite High
Toxicity 4 73.04 Quite High
Alzheimer's Dementia 12 50.00 Quite Low
INFLAMMATION 18 45.68 Quite Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Amyloid Plaque 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor-related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine augments the gene expression of serine racemase and DAO in rat brain.
Positive_regulation (augments) of Gene_expression (expression) of racemase in brain associated with agonist and morphine
1) Confidence 0.57 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.51
Repeated administration of morphine for 30 days produced a significant augmentation of both the mRNA and protein expressions of serine racemase in all the brain regions, whereas no significant change in the protein expression of DAO was observed in all the brain regions.
Positive_regulation (augmentation) of Gene_expression (expressions) of racemase in brain associated with morphine
2) Confidence 0.57 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.66
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
Positive_regulation (augments) of Gene_expression (expression) of racemase in brain associated with morphine
3) Confidence 0.56 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.41
RT-PCR of mRNA isolated from hippocampus of AD indicated a significant elevation of serine racemase expression compared to age-matched controls (AMC) (Fig. 7).
Positive_regulation (elevation) of Gene_expression (expression) of serine racemase in hippocampus associated with hippocampus and disease
4) Confidence 0.15 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.81 Pain Relevance 0.05
Serine racemase expression was detected in cultures of primary rat microglia and appeared to increase after activation with A?
Positive_regulation (increase) of Gene_expression (expression) of Serine racemase in microglia
5) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.06 Pain Relevance 0

General Comments

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