INT131185

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.31
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH, IGF1) extracellular region (PTH, IGF1) signal transduction (IGF1)
cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 6
PTH (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 38 99.68 Very High Very High Very High
Kinase C 1 78.24 Quite High
Inflammation 2 76.52 Quite High
cINOD 2 68.72 Quite High
antagonist 1 60.16 Quite High
COX2 2 25.00 Low Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 40 99.68 Very High Very High Very High
Osteoporosis 36 92.40 High High
Apoptosis 8 86.24 High High
Sclerosis 6 82.72 Quite High
INFLAMMATION 4 76.52 Quite High
Osteophyte 2 75.44 Quite High
Hypercalcemia 10 42.52 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Femoral Fractures 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob.
PTH Positive_regulation (stimulators) of Gene_expression (production) of IGF-1 in parathyroid associated with osteoarthritis
1) Confidence 0.44 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.48 Pain Relevance 0.62
As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob.
parathyroid hormone Positive_regulation (stimulators) of Gene_expression (production) of IGF-1 in parathyroid associated with osteoarthritis
2) Confidence 0.44 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.49 Pain Relevance 0.62
Parathyroid hormone plays an important role in IGF-1 action, because parathyroid hormone increases the production of IGF-1 by bone cells.
parathyroid hormone Positive_regulation (increases) of Gene_expression (production) of IGF-1 in parathyroid
3) Confidence 0.35 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

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