INT131187

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 11.18
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
chondrocytes 6
liver 4
PGE2 4
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 137 100.00 Very High Very High Very High
COX2 10 100.00 Very High Very High Very High
agonist 91 99.90 Very High Very High Very High
Dopamine 89 99.72 Very High Very High Very High
Somatostatin 77 98.64 Very High Very High Very High
cINOD 15 97.68 Very High Very High Very High
Inflammation 114 97.52 Very High Very High Very High
Pain 53 91.68 High High
abdominal pain 2 86.56 High High
rheumatoid arthritis 108 84.00 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 140 100.00 Very High Very High Very High
Hypoglycemia 54 99.64 Very High Very High Very High
Sclerosis 6 99.60 Very High Very High Very High
Acromegaly 79 98.88 Very High Very High Very High
Laron Syndrome 60 98.72 Very High Very High Very High
Liver Disease 10 98.64 Very High Very High Very High
Cancer 173 98.56 Very High Very High Very High
Nutritional Deficiencies 20 98.32 Very High Very High Very High
Diabetes Mellitus 23 98.26 Very High Very High Very High
Obesity 154 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondary or acquired GHI is characterized by GH–IGF-1 axis dysfunction due to malnutrition, liver diseases, catabolic illness, or neutralizing antibodies to growth hormones, affecting IGF-1 production and action.
Regulation (affecting) of Gene_expression (production) of IGF-1 in liver associated with liver disease, laron syndrome and nutritional deficiencies
1) Confidence 0.62 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.80 Pain Relevance 0
In conclusion, 3-month intervention with lycopene or fish oil supplement had no effect on normal prostate expression of IGF-1 and COX-2 (respectively) among men on AS for low-burden prostate cancer.
Neg (no) Regulation (effect) of Gene_expression (expression) of IGF-1 associated with prostate cancer
2) Confidence 0.57 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0.26 Pain Relevance 0
Indications for treatment of severe IGF-1 deficiency
Regulation (severe) of Gene_expression (deficiency) of IGF-1
3) Confidence 0.45 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.33 Pain Relevance 0
In these conditions the GH secretion is normal but peripheral effects is compromised with low or very low levels of serum IGF-1, due to a type of GH resistance or more often to alteration of IGF-1 production from the liver.2,10
Regulation (alteration) of Gene_expression (production) of IGF-1 in liver
4) Confidence 0.45 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.81 Pain Relevance 0
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Regulation (stimulation) of Gene_expression (synthesis) of IGF-1 in PGE2
5) Confidence 0.45 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.53 Pain Relevance 0.69
These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA.
Regulation (important) of Gene_expression (levels) of IGF-1 in PGE2 associated with sclerosis and osteoarthritis
6) Confidence 0.45 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.20 Pain Relevance 0.55
The management of her diabetes was also more effective (with fewer episodes of severe hypoglycaemia) when her GH and IGF-1 levels were controlled.
Regulation (controlled) of Gene_expression (levels) of IGF-1 associated with hypoglycemia and diabetes mellitus
7) Confidence 0.44 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.76 Pain Relevance 0.09
Canalis and Avioli have postulated that reduced IGF-1 synthesis may be responsible for the inhibition of bone formation caused by steroids [48].
Spec (may) Regulation (responsible) of Gene_expression (synthesis) of IGF-1
8) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.30 Pain Relevance 0.03
, and indeed raised IGF-1 mRNA levels above control levels despite the presence of IL-1?
Regulation (indeed) of Gene_expression (levels) of IGF-1 mRNA
9) Confidence 0.41 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.08 Pain Relevance 0.04
IGF-1 gene expression in chondrocytes
Regulation (chondrocytes) of Gene_expression (expression) of IGF-1 gene in chondrocytes
10) Confidence 0.41 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.12 Pain Relevance 0.06
At the moment, only two studies have investigated the long term effect of rhIGF1 therapy in IGFD patients: one by the European Study Group including 33 patients treated from 48 up to 72 months29 and another by the American Study Group comprising 76 patients treated up to 12 years under a predominantly open label design.31
Spec (investigated) Regulation (effect) of Gene_expression (therapy) of rhIGF1
11) Confidence 0.39 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.05 Pain Relevance 0
RESULTS: A total of 13 cases of injection-site lipoatrophy were reported, of which ten were in females and three occurred after the first injection; all cases were independent of PEG-GH dose or IGF1 levels, either basal or under treatment.
Neg (independent) Regulation (independent) of Gene_expression (dose) of IGF1
12) Confidence 0.39 Published 2009 Journal Eur. J. Endocrinol. Section Body Doc Link 19654233 Disease Relevance 0 Pain Relevance 0
Chondrocytes from obese OA patients exhibited an opposite response to the adipokine with a lack of significant effect on IGF-1 expression at 100 ng/ml but a strong up-regulation of IGF-1 at 500 ng/ml of leptin (Figure 2).
Regulation (effect) of Gene_expression (expression) of IGF-1 in Chondrocytes associated with obesity and osteoarthritis
13) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.70 Pain Relevance 0.05
We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis.


Regulation (regulate) of Gene_expression (expression) of insulin-like growth factor-1 associated with inflammation and cox2
14) Confidence 0.25 Published 2010 Journal Cancer Causes Control Section Abstract Doc Link PMC3002170 Disease Relevance 0.44 Pain Relevance 0.10
Comparable changes in IGF-1 gene expression were noted in cultured human chondrocytes.


Regulation (changes) of Gene_expression (expression) of IGF-1 gene in chondrocytes
15) Confidence 0.25 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1971260 Disease Relevance 0.07 Pain Relevance 0.07
Serum IGF-1 levels were unaltered by treatments.


Regulation (unaltered) of Gene_expression (levels) of IGF-1
16) Confidence 0.24 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2131759 Disease Relevance 0.56 Pain Relevance 0.47
Dopamine agonists can control GH and/or IGF-1 levels in 15-40% of patients with acromegaly [112,113].
Regulation (control) of Gene_expression (levels) of IGF-1 associated with acromegaly, dopamine and agonist
17) Confidence 0.16 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 1.62 Pain Relevance 0.69
First-line therapy with somatostatin analogues in patients with previously untreated acromegaly has received considerable attention since Newman et al showed that primary therapy with subcutaneous octreotide was as effective as adjuvant therapy with subcutaneous octreotide (following surgery or radiotherapy) at controlling GH and IGF-1 levels in patients with large or invasive tumors without visual or neurological disturbances [98].
Regulation (controlling) of Gene_expression (levels) of IGF-1 associated with acromegaly, cancer and somatostatin
18) Confidence 0.16 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.44 Pain Relevance 0.09
In comparison, local IGF-I production within target tissues is regulated by both GH-dependent and -independent mechanisms.
Regulation (regulated) of Gene_expression (production) of IGF-I
19) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.51 Pain Relevance 0.10
Hormones known to exert effects on bone turnover in part regulate IGF-1 expression.
Regulation (regulate) of Gene_expression (expression) of IGF-1
20) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.49 Pain Relevance 0

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