INT131194

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
extracellular region (Pdyn) nucleolus (Creb1) nucleus (Creb1)
Anatomy Link Frequency
neurons 2
Creb1 (Rattus norvegicus)
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 8 100.00 Very High Very High Very High
substance P 1 99.88 Very High Very High Very High
Dynorphin 1 99.56 Very High Very High Very High
Neuropeptide 5 88.64 High High
agonist 4 87.60 High High
Intracerebroventricular 1 85.60 High High
Nucleus accumbens 4 80.00 Quite High
dopamine receptor 1 75.00 Quite High
Enkephalin 2 25.00 Low Low
addiction 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Eating Disorder 1 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal neurons that express the D-1 DA receptor coexpress dynorphin and substance P, and CREB is known to couple D-1 DA receptor stimulation to preprodynorphin (ppD) gene expression.
CREB Positive_regulation (couple) of Gene_expression (expression) of preprodynorphin in neurons associated with dopamine, dynorphin and substance p
1) Confidence 0.26 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.08 Pain Relevance 0.79

General Comments

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