INT131195

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Drd1a) nucleoplasm (Creb1) mitochondrion (Creb1)
endoplasmic reticulum (Drd1a) intracellular (Drd1a) DNA binding (Creb1)
Anatomy Link Frequency
neurons 4
Creb1 (Rattus norvegicus)
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 47 100.00 Very High Very High Very High
substance P 1 99.88 Very High Very High Very High
Dynorphin 1 99.56 Very High Very High Very High
cerebral cortex 37 97.00 Very High Very High Very High
nMDA receptor 1 96.44 Very High Very High Very High
addiction 3 91.32 High High
agonist 5 87.60 High High
dopamine receptor 13 86.96 High High
Intracerebroventricular 1 85.60 High High
Neuropeptide 6 85.36 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 11 94.28 High High
Drug Dependence 2 91.32 High High
Diabetes Mellitus 90 82.68 Quite High
Eating Disorder 1 77.92 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dudman et al [64] reported that D2 receptors activate the cAMP response element-binding protein in neurons and D1 receptor stimulation leads to phosphorylation of the transcription factor Ca2+ and CREB in the nucleus by means of NMDA receptor-mediated Ca 2+ signaling.
cAMP response element-binding protein Positive_regulation (leads) of Positive_regulation (stimulation) of D1 receptor in neurons associated with nmda receptor
1) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.44
Striatal neurons that express the D-1 DA receptor coexpress dynorphin and substance P, and CREB is known to couple D-1 DA receptor stimulation to preprodynorphin (ppD) gene expression.
CREB Positive_regulation (couple) of Positive_regulation (stimulation) of D-1 DA receptor in neurons associated with dopamine, dynorphin and substance p
2) Confidence 0.27 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.08 Pain Relevance 0.78

General Comments

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