INT131199

Context Info Confidence 0.08 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 4.98 Pain Relevance 4.65

cytoplasm (C7orf49)

Anatomy Link Frequency primary somatosensory cortex 4 nucleus accumbens 2 anterior 1 insula 1 C7orf49 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 370 99.74 Anterior cingulate cortex 101 99.68 Transcranial magnetic stimulation 4 99.12 Inflammation 1 98.80 Neuropathic pain 25 98.38 Nucleus accumbens 6 98.00 imagery 52 97.00 antagonist 1 93.40 primary somatosensory cortex 3 92.72 insula 43 91.52

Disease Link Frequency Relevance Heat Anxiety Disorder 41 99.88 Pain 445 99.34 INFLAMMATION 1 98.80 Tics 306 98.68 Neuropathic Pain 49 98.38 Shock 33 96.48 Obsessive-compulsive Disorder 9 95.52 Headache 21 75.00 Stroke 26 67.52 Autism 20 66.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens.

Positive_regulation (induces) of Positive_regulation (activation) of fMRI in nucleus accumbens associated with pain and nucleus accumbens

1) Confidence 0.08 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16257488 Disease Relevance 0 Pain Relevance 0.63

Further, neuropathic pain patients would be expected to have reduced pain-evoked potential amplitudes but increased fMRI activation, different from volunteer or inflammatory models/conditions.

Positive_regulation (increased) of Positive_regulation (activation) of fMRI associated with pain, inflammation and neuropathic pain

2) Confidence 0.06 Published 2008 Journal BMC Anesthesiol Section Body Doc Link PMC2625333 Disease Relevance 0.99 Pain Relevance 1.43

While passive movements caused some increase in activation, active training led to more prominent increases in fMRI activation, recruitment curves (TMS) and intracortical facilitation (TMS).

Positive_regulation (increases) of Positive_regulation (activation) of fMRI associated with transcranial magnetic stimulation

3) Confidence 0.01 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2542391 Disease Relevance 0.12 Pain Relevance 0.23

Increased fMRI activation for both evoked and spontaneous tics was observed throughout cortical and subcortical structures commonly observed in experimental pain studies with healthy subjects; including the primary somatosensory cortex, insula, anterior cingulate, and thalamus.

Positive_regulation (Increased) of Positive_regulation (activation) of fMRI in primary somatosensory cortex associated with pain, primary somatosensory cortex, tics, insula, thalamus and anterior cingulate

4) Confidence 0.01 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2217520 Disease Relevance 1.17 Pain Relevance 0.69

Relative to controls, individuals with OCD show increased fMRI activation of the ACC and increased ERN amplitude not only to error trials (Gehring et al., 2000; Johannes et al., 2001; Fitzgerald et al., 2005; but see Nieuwenhuis et al., 2005 for a negative finding), but also to correct trials with high response-conflict (i.e. those that require suppression of a competing response) in some (Ursu et al., 2003; Maltby et al., 2005), but not all studies (Gehring et al., 2000; Fitzgerald et al., 2005).

Positive_regulation (increased) of Positive_regulation (activation) of fMRI associated with anxiety disorder and anterior cingulate cortex

5) Confidence 0.01 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0.36 Pain Relevance 0.30

Increased fMRI activation for both evoked and spontaneous tics was observed throughout cortical and subcortical structures commonly observed in experimental pain studies with healthy subjects; including the primary somatosensory cortex, insula, anterior cingulate, and thalamus.

Positive_regulation (Increased) of in insula Positive_regulation (activation) of fMRI in primary somatosensory cortex associated with pain, primary somatosensory cortex, tics, insula, thalamus and anterior cingulate

6) Confidence 0.00 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2217520 Disease Relevance 1.17 Pain Relevance 0.69

Increased fMRI activation for both evoked and spontaneous tics was observed throughout cortical and subcortical structures commonly observed in experimental pain studies with healthy subjects; including the primary somatosensory cortex, insula, anterior cingulate, and thalamus.

Positive_regulation (Increased) of in anterior Positive_regulation (activation) of fMRI in primary somatosensory cortex associated with pain, primary somatosensory cortex, tics, insula, thalamus and anterior cingulate

7) Confidence 0.00 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2217520 Disease Relevance 1.17 Pain Relevance 0.69

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