INT131228

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 134 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
cytokine 13 99.96 Very High Very High Very High
Pain 7 98.52 Very High Very High Very High
Antinociceptive 5 98.40 Very High Very High Very High
agonist 63 98.16 Very High Very High Very High
qutenza 2 81.36 Quite High
substance P 1 79.00 Quite High
bradykinin 2 77.80 Quite High
Hyperalgesia 1 76.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 147 100.00 Very High Very High Very High
Pain 5 98.52 Very High Very High Very High
Chemotherapy-induced Neutropenia 1 81.28 Quite High
Hyperalgesia 1 76.92 Quite High
Corneal Neovascularization 6 75.08 Quite High
Chemical Burns 6 64.12 Quite High
Pleurisy 16 58.80 Quite High
Nociception 1 52.16 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 48.84 Quite Low
Disease 24 42.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of S100A8 inhibited S-CorNV and inflammation
Regulation (inflammation) of Localization (Depletion) of S100A8 associated with inflammation
1) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.13
The precise mechanism responsible for the antinociceptive effect of the extract still remains unclear, but seems to be partly related to modulation of the release or action of pro-inflammatory mediators involved in the models of pain used.
Regulation (modulation) of Localization (release) of pro-inflammatory associated with pain, inflammatory mediators and antinociceptive
2) Confidence 0.23 Published 2005 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16259764 Disease Relevance 0.62 Pain Relevance 0.88
Effects of T0901317 on the release of pro-inflammatory cytokine induced by carrageenan
Regulation (Effects) of Localization (release) of pro-inflammatory associated with inflammation and cytokine
3) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.30 Pain Relevance 0.17
changes in the synthesis and/or release of pro-inflammatory
Regulation (changes) of Localization (release) of pro-inflammatory associated with inflammation
4) Confidence 0.01 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.41 Pain Relevance 0.47

General Comments

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