INT131249

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.00
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
extracellular region (Bdnf) plasma membrane (Ntrk2) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 4
spinal 2
sympathetic 1
Bdnf (Rattus norvegicus)
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 47 100.00 Very High Very High Very High
antidepressant 41 100.00 Very High Very High Very High
Glutamate receptor 4 99.24 Very High Very High Very High
allodynia 22 98.72 Very High Very High Very High
c fibre 8 98.44 Very High Very High Very High
Nerve growth factor 16 97.64 Very High Very High Very High
Spinal cord 77 96.16 Very High Very High Very High
withdrawal 4 94.56 High High
Hippocampus 39 92.52 High High
Dorsal horn 6 92.08 High High
Disease Link Frequency Relevance Heat
Death 16 99.08 Very High Very High Very High
Neuropathic Pain 41 98.72 Very High Very High Very High
Apoptosis 32 97.48 Very High Very High Very High
Injury 51 90.76 High High
Neurodegenerative Disease 6 89.68 High High
Pain 66 89.52 High High
Spinal Cord Injury 53 87.72 High High
INFLAMMATION 51 84.52 Quite High
Depression 121 75.52 Quite High
Stress 21 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tropomyosin-related kinase B (TrkB) receptor for brain-derived neurotrophic factor (BDNF) was expressed on aberrantly sprouted C-fibers.
BDNF Binding (receptor) of TrkB in brain associated with c fibre
1) Confidence 0.41 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19222991 Disease Relevance 0.77 Pain Relevance 0.99
Tropomyosin-related kinase B (TrkB) receptor for brain-derived neurotrophic factor (BDNF) was expressed on aberrantly sprouted C-fibers.
brain-derived neurotrophic factor Binding (receptor) of TrkB in brain associated with c fibre
2) Confidence 0.41 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19222991 Disease Relevance 0.77 Pain Relevance 0.99
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF Binding (binds) of TrkB associated with antidepressant
3) Confidence 0.41 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.50
Brain-derived neurotrophic factor (BDNF) exerts its trophic effects by acting on the high-affinity specific receptor trkB.
Brain-derived neurotrophic factor Binding (acting) of trkB in Brain
4) Confidence 0.31 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262634 Disease Relevance 0.37 Pain Relevance 0.44
Brain-derived neurotrophic factor (BDNF) exerts its trophic effects by acting on the high-affinity specific receptor trkB.
BDNF Binding (acting) of trkB in Brain
5) Confidence 0.31 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262634 Disease Relevance 0.37 Pain Relevance 0.44
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF Binding (binds) of TrkB associated with antidepressant
6) Confidence 0.31 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.52
When BDNF interacts with tyrosine receptor kinase receptors (TRkB), it promotes cellular resilience and long-term potentiation.
BDNF Binding (interacts) of TRkB associated with long-term potentiation
7) Confidence 0.14 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 0.99 Pain Relevance 0.67
For instance, when sympathetic neurons, expressing p75 and TrkA surface receptors, were presented with the neurotrophic molecule BDNF, subsequent binding of BDNF to the p75NTR without binding to TrkB ultimately led to the death of the neurons via p75NTR induced apoptosis [76,77].
BDNF Binding (binding) of TrkB in sympathetic associated with apoptosis and death
8) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.32 Pain Relevance 0.11
Thus, BDNF-LTP is associated with rapid and transient phosphorylation of two translation factors critical in controlling global translation initiation and elongation rates, eukaryotic initiation factor 4E (eIF4E), and elongation factor-2 (eEF2) [62].
BDNF-LTP Binding (associated) of factors associated with long-term potentiation
9) Confidence 0.11 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.48
Binding of brain-derived neurotrophic factor (BDNF) to its specific TrkB receptor is also important for spinal activation of the ERK pathway [85, 100] (Fig. 3).
brain-derived neurotrophic factor Binding (Binding) of TrkB receptor in spinal
10) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.21 Pain Relevance 0.56
Binding of brain-derived neurotrophic factor (BDNF) to its specific TrkB receptor is also important for spinal activation of the ERK pathway [85, 100] (Fig. 3).
BDNF Binding (Binding) of TrkB receptor in spinal
11) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.21 Pain Relevance 0.56

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