INT131253

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.28
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
astrocytes 3
endothelial cells 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 22 99.68 Very High Very High Very High
Eae 2 99.08 Very High Very High Very High
intrathecal 12 98.80 Very High Very High Very High
Sciatic nerve 5 97.64 Very High Very High Very High
Antihyperalgesic 1 93.56 High High
antiallodynic 1 92.72 High High
Inflammation 4 89.32 High High
Neuropathic pain 6 87.80 High High
allodynia 9 86.56 High High
cytokine 21 85.52 High High
Disease Link Frequency Relevance Heat
Injury 2 99.08 Very High Very High Very High
Nervous System Injury 4 97.92 Very High Very High Very High
INFLAMMATION 7 89.32 High High
Neuropathic Pain 15 87.80 High High
Pain 16 83.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 69.68 Quite High
Necrosis 3 51.52 Quite High
Cancer 3 51.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To reveal NF-kappaB activation, we assessed inhibitory factor kappaBalpha (IkappaBalpha) mRNA expression by in situ hybridization, as NF-kappaB activation up-regulates IkappaBalpha gene expression as part of an autoregulatory feedback loop.
Positive_regulation (up-regulates) of Gene_expression (expression) of IkappaBalpha
1) Confidence 0.41 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.93 Pain Relevance 1.27
Concomitantly, IkappaBalpha overproduction prevented the enhanced expression of interleukin-6 and of inducible nitric oxide synthase associated with chronic constriction injury and resulted in prolonged antihyperalgesic and antiallodynic effects.
Positive_regulation (overproduction) of Gene_expression (overproduction) of IkappaBalpha associated with antihyperalgesic, eae, injury and antiallodynic
2) Confidence 0.40 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 0.94 Pain Relevance 1.15
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
3) Confidence 0.38 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.14
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Positive_regulation (induced) of in endothelial cells Gene_expression (expression) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
4) Confidence 0.13 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.14

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