INT131257

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, Nfkbia) cytoplasm (ITIH4, Nfkbia) cytosol (Nfkbia)
extracellular region (ITIH4) nucleus (Nfkbia) enzyme binding (Nfkbia)
Anatomy Link Frequency
astrocytes 3
endothelial cells 1
ITIH4 (Homo sapiens)
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 12 100.00 Very High Very High Very High
intrathecal 8 100.00 Very High Very High Very High
cytokine 14 89.28 High High
Inflammation 2 81.40 Quite High
Sciatic nerve 2 80.88 Quite High
Neuropathic pain 2 79.88 Quite High
allodynia 6 78.64 Quite High
Pain 12 75.00 Quite High
Inflammatory mediators 2 57.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 81.40 Quite High
Neuropathic Pain 8 79.88 Quite High
Pain 8 75.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 61.76 Quite High
Necrosis 2 43.60 Quite Low
Cancer 2 43.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
gp120 Positive_regulation (induced) of Gene_expression (expression) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
1) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.15
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
gp120 Positive_regulation (induced) of in endothelial cells Gene_expression (expression) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
2) Confidence 0.08 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.15

General Comments

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