INT131263

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.11
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
Caco-2 2
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 98.72 Very High Very High Very High
Pain 147 97.48 Very High Very High Very High
Potency 4 97.12 Very High Very High Very High
Pain score 14 96.08 Very High Very High Very High
cytokine 11 89.00 High High
Inflammation 94 88.20 High High
rheumatoid arthritis 22 78.72 Quite High
nociceptor 14 75.68 Quite High
Analgesic 7 28.04 Quite Low
spinal inflammation 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 483 100.00 Very High Very High Very High
Infection 111 98.68 Very High Very High Very High
Pain 154 97.48 Very High Very High Very High
Disease 69 94.72 High High
Metatarsalgia 189 93.16 High High
INFLAMMATION 104 88.20 High High
Obesity 28 87.80 High High
Dengue 130 82.52 Quite High
Body Weight 7 78.84 Quite High
Rheumatoid Arthritis 29 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Replacement or changing to different-sized MPs should be considered when MP placement fails to achieve PTI and MPP reduction by insole plantar pressure measurement.
Negative_regulation (reduction) of MPP
1) Confidence 0.49 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.19 Pain Relevance 0.14
We found that the decline in the PTI value after MP placement correlated well with that in the VAS scores, while the decline in the MPP value correlated moderately (r = 0.77, R2 = 0.59 versus r = 0.60, R2 = 0.36).
Negative_regulation (decline) of MPP
2) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.80 Pain Relevance 0.66
After MP placement, the MPP and PTI of all the subjects decreased significantly; their values were 199.0 (95% CI, 163.3–234.8) kPa and 31.9 (95% CI, 24.3–39.5) kPa·s, respectively.
Negative_regulation (decreased) of MPP
3) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.40 Pain Relevance 0
MP application decreased the maximal peak pressure (MPP) and pressure-time integral (PTI) under the second MH and also statistically improved subjective pain scores.
Negative_regulation (decreased) of MPP associated with pain score
4) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.67 Pain Relevance 0.23
We found that the successful decline in the PTI and MPP under the second MH after MP application was correlated to subjective pain improvement.
Negative_regulation (decline) of MPP associated with pain
5) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.56 Pain Relevance 0.23
We found that the declines in the PTI and MPP under the MH after MP application correlated with significant pain improvement.
Negative_regulation (declines) of MPP associated with pain
6) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.22 Pain Relevance 0.16
We found that the decline in the MPP and PTI after MP placement differed significantly in each outcome group (p = 0.033 and p = 0.034, respectively).
Negative_regulation (decline) of MPP
7) Confidence 0.36 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0 Pain Relevance 0
IFN type I-related transcripts, of which abundance was shown to be decreased in DSS patients by others [27], [28], [42], represented only a limited number of genes associated with the DSS-gene signature.
Negative_regulation (decreased) of DSS associated with dengue hemorrhagic fever
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.08 Pain Relevance 0.17
The uptake of [3H]MPP+ into Caco-2 cells was inhibited by atropine, butylscopolamine, clonidine, diphenhydramine, etilefrine, quinine and ranitidine with IC50 values between 6 microM and 4 mM.
Negative_regulation (inhibited) of MPP in Caco-2 associated with clonidine
9) Confidence 0.15 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16263091 Disease Relevance 0 Pain Relevance 0.17
Transepithelial, apical to basal flux of [3H]MPP+ across Caco-2 cell monolayers was also strongly inhibited by these compounds.
Negative_regulation (inhibited) of MPP in Caco-2
10) Confidence 0.15 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16263091 Disease Relevance 0 Pain Relevance 0.19
Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P?
Negative_regulation (decreased) of DSS associated with dengue hemorrhagic fever and infection
11) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2553281 Disease Relevance 2.36 Pain Relevance 0
As shown in Table 8, HLA-DRB1*0901 frequency was significantly decreased in DSS compared with DHF among DEN-2- positive patients (OR?
Negative_regulation (decreased) of DSS associated with dengue hemorrhagic fever
12) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 0.83 Pain Relevance 0

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